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mühlberger elke (curatore); hensley lisa l. (curatore); towner jonathan s. (curatore) - marburg- and ebolaviruses

Marburg- and Ebolaviruses From Ecosystems to Molecules

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 01/2018
Edizione: 1st ed. 2017





Trama

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy.

For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure.

Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.





Sommario

Filovirus Research: How it began.- Ecology of Filoviruses.- West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis.- Clinical Management of Ebola Virus Disease Patients in Low Resource Settings.- Clinical Management of Patients with Ebola Virus Disease in High Resource Settings.- Ebola Virus Disease in Humans: Pathophysiology and Immunity.- Nonhuman Primate Models of Ebola Virus Disease.- Small Animal Models for Studying Filovirus Pathogenesis.- Accelerating Vaccine Development during the West African Ebola Virus Disease Outbreak.- Therapeutics against Filovirus Infection.-  Filovirus Strategies to Escape Antiviral Responses.- Mechanisms of Filovirus Entry.- Inside the Cell: Assembly of Filoviruses.- Filovirus Structural Biology: The Molecules in the Machine.- Reverse Genetics of Filoviruses.- Guide to the Correct Use of Filoviral Nomenclature.





Autore

Elke Mühlberger
Boston University School of Medicine 
Boston, MA, USA
e-mail: muehlber@bu.edu

Lisa L. Hensley
National Institutes of Health
NIAID
Frederick, MD, USA
e-mail: Lisa.Hensley@nih.gov

Jonathan S. Towner
Centers for Disease Control & Prevention
Atlanta, GA, USA
e-mail: jit8@cdc.gov










Altre Informazioni

ISBN:

9783319689463

Condizione: Nuovo
Collana: Current Topics in Microbiology and Immunology
Dimensioni: 235 x 155 mm Ø 1077 gr
Formato: Copertina rigida
Illustration Notes:X, 460 p.
Pagine Arabe: 460
Pagine Romane: x


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