Malaria Control and Elimination

This detailed book serves to provide a global overview of the goals, rationale, and scientific basis for malaria control and elimination, as well as tools, methods, and strategies to that end. Opening with a section on malaria epidemiology, the volume continues by covering tools that are critical to malaria management, anti-malarial drugs and resistance to these drugs, vaccination approaches against malaria, vector control, as well as some perspective on the future of the fight against this devastating disease. Written for the highly successful Method in Molecular Biology series, chapters in this collection feature the kind of practical, hands-on advice that leads to better results in the field. 

Part I: Epidemiology

 

1. Country-Owned, Country-Driven: Perspectives from the World Health Organization on Malaria Elimination

            Kim A. Lindblade, Li Xiao Hong, Gawrie Loku Galappaththy, Abdisalan Noor, Jan Kolaczinski, and Pedro L. Alonso

 

2. Current Situation of Malaria in Africa

            Wilfred Fon Mbacham, Lawrence Ayong, Magellan Guewo-Fokeng, and Valerie Makoge

 

3. Current Malaria Situation in Asia-Oceania

            Chansuda Wongsrichanalai, Rossitza Kurdova-Mintcheva, and Kevin Palmer

 

4. Malaria Situation in Latin America and the Caribbean: Residual and Resurgent Transmission and Challenges for Control and Elimination

            Marcelo U. Ferreira and Marcia C. Castro

 

Part II: Methods

 

5. Diagnosing Malaria: Methods, Tools, and Field Applicability

            Lawrence Ayong, Carole Eboumbou, and Wilfred F. Mbacham

 

6. Serological Profiling for Malaria Surveillance Using a Standard ELISA Protocol

            Linda M. Murungi, Rinter K. Kimathi, James Tuju, Gathoni Kamuyu, and Faith H.A. Osier

 

7. Controlled Human Malaria Infection (CHMI) Studies: Over 100 Years of Experience with Parasite Injections

            Kai Matuschewski and Steffen Borrmann

 

Part III: Therapeutics

 

8. In Vivo Assessments to Detect Antimalarial Resistance

            Mehul J. Dhorda and Adrianus M. Dondorp

 

9. Plasmodium falciparum In Vitro Drug Resistance Selections and Gene Editing

            Caroline L. Ng and David A. Fidock

 

10. An Update on Artemisinin Resistance

            Frédéric Ariey and Didier Ménard

 

11. Antimalarial Drugs for Malaria Elimination

            Jerome Clain, Abderaouf Hamza, and Frédéric Ariey

 

Part IV: Vaccinology

 

12. Vaccine Development: From Preclinical Studies to Phase 1/2 Clinical Trials

            Cécile Artaud, Leila Kara, and Odile Launay

 

13. The Advanced Development Pathway of the RTS,S/AS01 Vaccine

            Lorenz von Seidlein

 

14. Live Vaccines against Plasmodium Pre-Erythrocytic Stages

            Laura Mac-Daniel and Robert Ménard

 

15. Development of Blood Stage Malaria Vaccines

            Aneesh Vijayan and Chetan E. Chitnis

 

Part V: Vector Control

 

16. Insecticide-Treated Mosquito Nets

            Pierre Carnevale and Frédérick Gay

 

17. Sampling Adult Populations of Anopheles Mosquitoes

            Julie-Anne A. Tangena, Alexandra Hiscox, and Paul T. Brey

 

18. Insecticides and Insecticide Resistance

            Mamadou Ousmane Ndiath

 

Part VI: Opinions

 

19. Herbal Remedies to Treat Malaria in Madagascar: Hype and Hope

            Arsène Indriambelo, Mamy Arilandy Rakotomamonjy, Rakotondrafara Andriamalala, Harison Rabarison, Michel Ratsimbason, Astrid Knoblauch, and Milijaona Randrianarivelojosia

 

20. Vade Retro Malaria: The Vagaries of Eradication Campaigns

            Georges Snounou