Macrophage Biology and Activation

The amazing world of the mononuclear phagocytes keeps expanding at a truly awesome pace. As a result, maintaining currency with the latest developments and controversies that pertain to this cell type is increasingly difficult. The aspects covered in this volume have been selected to provide an overview of subject areas that either have recently become much better understood or hold the promise of new levels of understanding as they are developed in the future. The scope of topics ranges from how these cells develop, through the means that are used to regulate them, to the roles that they have in different tissues and in a variety of infectious diseases.

List of Contents.- Antigen Markers of Macrophage Differentiation in Murine Tissues.- Macrophages in the Uterus and Placenta.- Urokinase-Catalyzed Plasminogen Activation at the Monocyte/Macrophage Cell Surface: A Localized and Regulated Proteolytic System.- Macrophage-Derived Growth Factors.- The Biology of CFS-1 and Its Receptor.- Lipopolysaccharide Receptors and Signal Transduction Pathways in Mononuclear Phagocytes.- The Role of Myristoylated Protein Kinase C Substrates in Intracellular Signaling Pathways.- Ribosomal RNA Metabolism in Macrophages.- Mononuclear Phagocytes as Targets, Tissue Reservoirs, and Immunoregulatory Cells in Human Immunodeficiency Virus Disease.- Interactions Between Macrophages and Legionella pneumophila.- Chronic Granulomatous Disease: An Update and a Paradigm of the Use of Interferon-? as Adjunct Immunotherapy in Infectious Diseases.