This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous ‘pathogen-associated molecular patterns’ or ‘damage-associated molecular patterns’. As such, microbes’ interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.
C-type Lectin Receptors in Antifungal Immunity.- Immune recognition of pathogen-derived glycolipids through Mincle.- CLEC5A: A promiscuous pattern recognition receptor to microbes and beyond.- Collectins: Innate immune pattern recognition molecules.- Insect C-type lectins in microbial infections.- Galectins in Host Defense against Microbial Infections.- Galectins in Host-Pathogen Interactions: Structural, Functional and Evolutionary Aspects.- Siglecs at the Host-Pathogen Interface.- Siglecs that associate with DAP12.
Dr. Shie-Liang Hsieh is a distinguished research fellow at the Genomics Research Center, Academia Sinica. He is also an adjunct professor at National Taiwan University, National Yang-Ming University and Taipei Medical University, and a distinguished research fellow at Taipei Veterans General Hospital. He serves on the editorial boards of several international journals, including the Journal of Molecular Medicine, and Pathogens and Disease. Prof. Hsieh’s research chiefly focuses on C-type lectins and Siglecs in host-pathogen interactions, neuroinflammation, and tissue repair. He has published more than 140 articles and book chapters in these fields.
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