Table of Contents; Contributors; Preface; SECTION 1: Introduction to Late-Life Mood Disorders; 1. A National Institute of Mental Health (NIMH) Perspective on Geriatric Mood Disorder Research; Jovier D. Evans and George T. Niederehe; 2. Research Priorities in Late Life Mood Disorders: An International Perspective; Briony Dow, David Ames, Xiaoping Lin, Jean Tinney, and Betty Harambous; 3. Epidemiology of Late Life Mood Disorders: Rates, Measures and Populations; Patricia Marino and Jo Anne Sirey; 4. Public Health Burden of Late-Life Mood Disorders; J?rgen Un?tzer and Mijung Park; 5. Late Onset Mood Disorders: ICDs and DSMs; Roger Peele; Section 2: Diagnosis and Comorbid Conditions; 6. The Diagnosis and Treatment of Unipolar Depression in Late Life; John Snowdon and Osvaldo P. Almeida; 7. Bipolar Disorder; Robert C. Young and Nahla A. Mahgoub; 8. Non-Major Depression; Ganesh Kulkarni, Ipsit V. Vahia, Thomas W. Meeks and Dilip V. Jeste; 9. Anxious Depression: Application of a Unified Model of Emotional Disorders to Older Adults; Andrew J. Petkus, Eric J. Lenze and Julie Loebach Wetherell; 10. The Social Determinants of Depression in Older Adulthood; Stephen E. Gilman, Hannah Carliner and Alex Cohen; 11. Depression in Dementia; Christopher M. Marano, Paul B. Rosenberg and Constantine G. Lyketsos; 12. The Challenge of Suicide Prevention in Later Life; Yeates Conwell and Alisa O'Riley; 13. Bereavement and Complicated Grief in Older Adults; Katherine M. Shear, Angela Ghesquiere and Michael S. Katzke; 14. Current Issues in Informal Caregiving Research: Prevalence, Health Effects and Intervention Strategies; Richard Schulz; 15. Post-Stroke Depression and Vascular Depression; Sarah Volk and David C. Steffens; 16. Depression and Medical Illness in Late Life: Race, Resources, and Stress; Briana Mezuk and Joseph J. Gallo; 17. Comorbid Neurological Illness; Dylan Wint and Jeffrey Cummings; 18. Comorbid Substance Abuse; David W. Oslin and Amy Helstrom; 19. Comorbid Pain Disorders; Jordan F. Karp and Jonathan McGovern; 20. Bidirectional relationships between sleep, insomnia and depression; Chiara Baglioni, Mathias Berger, and Dieter Riemann; Section 3: Treatment and prevention; 21. Use of adjunctive therapy in older depressed adults who are resistant to antidepressant treatment; J. Craig Nelson; 22. Psychotherapy; Patricia A. Arean; 23. ECT and Neuromodulation in the Treatment of Late-Life Mood Disorders; William M. McDonald and Arshya Vahabzadeh; 24. Complementary and Alternative Medicine (CAM) Approaches for Treatment and Prevention in Late-Life Mood Disorders; David Merrill, Martha Payne and Helen Lavretsky; 25. Prevention of Depression in Later Life: A Developmental Perspective; Aartjan T.F. Beekman, Pim Cuipers and Filip Smit; 26. Depression Medication Treatment Adherence in Later Life; Kara Zivin, Janet Kavanagh, Susan M. Maixner, Jo Anne Sirey and Helen C. Kales; Section 4: Care Delivery Systems; 27. Depression in Long-term Care; Christina Hui and David L. Sultzer; 28. Late Life Depression in the Primary Care Setting: Toward a Patient-Centered Future; Marsha Wittink, Paul Duberstein and Jeffrey M. Lyness; 29. Depression in Older Adults Receiving Hospice Care; Abhilash K. Desai, Daphne T. Lo and George T. Grossberg; 30. Late Life Mood Disorders and Home-based Services and Interventions; Kisha N. Bazelais, Yolonda R. Pickett and Martha L. Bruce; 31. Novel Platforms for Care Delivery: Internet-based Interventions and Telepsychiatry; Pim Cuipers, Heleen Riper and Aartjan Beekman; Section 5: Neurobiology and Biomarkers; 32. Structural Neuroimaging in Late Life Mood Disorders; Sean J. Colloby and John T. O'Brien; 33. Molecular Neuroimaging in Late Life Mood Disorders; Anand Kumar, Olusola Ajilore, Brent Forester, Jaime Deseda, Matthew Woodward and Emma Rhodes; 34. Functional Neuroimaging in Late Life Mood Disorders; Meenal J. Patel, Howard J. Aizenstein and Gwenn S. Smith; 35. Cognitive Biomarkers in Depression; Oliver J. Robinson and Barbara J. Sahakian; 36. Neuropathological Markers in Late-Life Depression; Jos? Javier Miguel-Hidalgo and Grazyna Rajkowska; 37. Pharmacogenetics; Greer M. Murphy, Jr.; 38. Pharmacokinetics and Pharmacodynamics in Late Life; Kristin L. Bigos, Robert R. Bies and Bruce G. Pollock; 39. Psychoneuroimmunology of Depressive Disorders: Implications for Older Adults and Late-Life Depression; Michael R. Irwin; 40. The HPA Axis and Late Life Depression; Keith Sudheimer, John Flournoy, Anda Gershon, Bevin Demuth, Alan Schatzberg and Ruth O'Hara; 41. Clinical Prediction Models; Wesley K. Thompson, Ji-in Choi and Stewart Anderson; 42. Integration of Biological, Clinical and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression; Linda Garand, Ellen M. Whyte, Meryl A. Butters, Elizabeth R. Skidmore, Jordan F. Karp and Mary Amanda Dew; 43. Conclusion; Helen Lavretsky, Martha Sajatovic and Charles Reynolds III; Index