Landmark Papers in Pain Seminal Papers in Pain with Expert Commentaries

Pain Medicine, a relatively new specialty, has proven increasingly relevant to medical practitioners in every field. The specialism of pain has emerged over the past 50 years, largely due to the persistence of experts and new medical evidence that points to its necessity. Today, it is a distinct and integral part of global medical practice. Landmark Papers in Pain offers a comprehensive inventory of over 80 key studies in pain medicine from the last 100 years. Each paper is accompanied by a concise commentary on the significance of the original findings written by an expert in pain. The reviews discuss how the paper influenced the development of the speciality, and how the findings have advanced our global comprehension of pain. Together, the selected papers and reviews chart the growth of an embryonic field into the modern speciality of pain medicine. Complied by leading specialists in the field, the papers included in this book are significant for any student, researcher, clinical practitioner, or medical historian interested in pain medicine. Organised into eight distinct topics and cross-referenced by topics and author of original paper, the book is comprehensive in its coverage and easy to use. A review of the contemporary and historical research that shaped the speciality of pain, Landmark Papers in Pain is essential reading for all medical practitioners with an interest in pain medicine.

1 - Local anaesthetic substitutes for cocaine
2 - Innovative concepts in pain management
3 - Explaining reflex sympathetic dystrophy
4 - The rediscovery of paracetamol
5 - The pharmacology of placebos
6 - Understanding the responsiveness of c-fibres
7 - A new theory of pain
8 - Three determinants of pain
9 - Purinergic nerves: a new type of nerve
10 - Genetic differences in opiate receptors
11 - Endogenous opioids in placebo-induced analgesia
12 - Ethical pain experimentation in conscious animals
13 - Local anaesthetic creams
14 - The backpain revolution
15 - The mechanism of aspirin
16 - Mechanisms of visceral pain in IBS
17 - The effects of morphine on the central nervous system
18 - Opiods in palliative care
19 - Endogenous opioids in the central nervous system
20 - Spinal opioid analgesia in the rat
21 - The key role of NGF in inflammatory pain processing
22 - Mapping of neurotrophin receptors on adult sensory neurons
23 - Plasticity in somatic receptive fields after nerve injury
24 - Peripheral neural mechanisms of cutaneous hyperalgesia and heat pain
25 - The Cloning and Characterization of CB1
26 - Deorphanisation of ORL-1/LC132 by reverse pharmacology in two landmark studies
27 - The capsaicin receptor
28 - Vanilloid receptor 1 in inflammatory thermal hyperalgesia
29 - A signature of pain in the brain
30 - Cytokines as central to peripheral sensitisation and hyperalgesia
31 - Endogenous opioids mediate stress-induced analgesia
32 - The first crystal structure of an iGluR ligand-binding core
33 - Control of pain initiation by endogenous cannabinoids
34 - Peripheral Analgesia involves Cannabinoid Receptors
35 - Glia: a new pain target
36 - The challenges of animal models of pain
37 - Mechanisms of bone cancer pain
38 - Molecular Structure of the Mu-Opioid Receptor
39 - Milestone Effect of DNIC in our Understanding of Pain
40 - Original description of central sensitisation
41 - Molecular basis for Placebo effect
42 - Early discussions on a mechanistic approach to pain
43 - Plasticity: a key concept in pain
44 - The importance of descending modulatory pain systems
45 - Nocebo and its importance in clinical practice
46 - Mechanisms of Action of Acetaminophen for Pain Treatment
47 - Making the link from central sensitization to clinical pain
48 - Proof of concept: epidural morphine
49 - The Definition of Fibromyalgia
50 - The advent of PCA for post operative analgesia
51 - Undertreatment of pain with metastatic cancer
52 - Faces scales in paediatric pain assessment
53 - Epidural block and phantom limb pain
54 - Clarifying the concept of Breakthrough pain
55 - Paediatric pain epidemiology
56 - Recognising the importance of HIV disease and pain
57 - Fast acting fentanyl for breakthrough pain
58 - The additive analgesia of adrenaline in epidural blockade
59 - What is the clinical relevance of the Likert scale for pain
60 - Post operative pain: assessing the standards
61 - Opioid induced hyperalgesia
62 - CRPS epidemiology
63 - Seminal paper on epidemiology of cancer pain
64 - Endoscopic ultrasound guided coeliac plexus block
65 - Autotomy: an early neuropathic pain model
66 - Risk factors for post amputation pain
67 - Chronic constriction injury (CCI) model of neuropathic pain
68 - Antineuropathic medication combination therapy
69 - RCT evidence for gabapentin in post herpetic neuralgia
70 - Identification of the target of gabapentinoid action in neuropathic pain
71 - Recognition of the importance of Neuropathic pain epidemiology
72 - Botox analgesia for neuropathic pain
73 - DNIC and prediction of chronic post surgical pain
74 - Pregabalin in the reduction of chronic post knee surgery chronic pain
75 - Multidisciplinary Cognitive Behavioural Treatment for Chronic Pain
76 - Disability in Chronic Low Back Pain
77 - The Understanding of Social Effects in Pain
78 - Congenital insensitivity to pain
79 - Polymorphic CYP2D6 as the Responsible Enzyme of Activation
80 - COMT genotypes in pain responses
81 - The link between NaV1.7 mutation and erythromelalgia
82 - COMT and morphine use in cancer pain
83 - Pioneering use of gene therapy for pain

Dr Paul Farquhar-Smith, MA, MB, BChirFRCA, PhD, FFPMRCA, FFICM, is at present a Consultant in Pain Medicine and Anaesthesia at The Royal Marsden NHS Foundation Trust in London, UK. He specialises in pain in cancer patients and survivors (post-surgical chronic pain, chemotherapy induced neuropathy), and anaesthesia for breast and reconstructive surgery. Dr Pierre Beaulieu is at present a Professor of Anesthesiology and Pharmacology at Université de Montréal in Canada. He specialises in the pharmacology and neurobiology of pain, the use of cannabinoids for treatment of pain, and in local anaesthetics Dr Siân Jaggar is at present a Consultant in Anaesthesia at Royal Brompton & Harefield NHS Foundation Trust in London, UK. She specialises in adult and paediatric cardiothoracic anaesthesia and pain relief. She has a particular interest in education as a tool to enhance understanding between different working groups. She is the Royal College deputy regional advisor for the North West Thames region and the lead for less than full time trainees in this region.