Introduction To Computational Genomics - Cristianini Nello; Hahn Matthew W. | Libro Cambridge University Press 12/2006 - HOEPLI.it


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cristianini nello; hahn matthew w. - introduction to computational genomics

Introduction to Computational Genomics A Case Studies Approach

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Dettagli

Genere:Libro
Lingua: Inglese
Pubblicazione: 12/2006





Trama

This readable and entertaining book provides a roadmap to navigate entry to the field of computational genomics in biology. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding, and other topics are introduced in a rigorous yet accessible way.




Note Editore

Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.




Sommario

Prologue (in praise of cells); 1. The first look at a genome (sequence statistics); 2. All the sequence's men (gene finding); 3. All in the family (sequence alignment); 4. The boulevard of broken genes (hidden Markov models); 5. Are Neanderthals among us? (variation within and between species); 6. Fighting HIV (natural selection at the molecular level); 7. SARS: a post-genomic epidemic (phylogenetic analysis); 8. Welcome to the hotel Chlamydia (whole genome comparisons); 9. The genomics of wine-making (analysis of gene expression); 10. A bed-time story (identification of regulatory sequences); Appendix.




Prefazione

Are we related to Neanderthals? Where did SARS come from? Such questions are answered by statistical and computational analysis of genetic data, and are the vehicle for this entertaining introduction to computational genomics. The case-studies approach with Matlab demos provides an enjoyable way to learn how to analyze genomic data first-hand.




Autore

Nello Cristianini is a Professor of Artificial Intelligence, University of Bristol.
Matthew Hahn is an Assistant Professor at the Department of Biology and School of Informatics, Indiana University.







Altre Informazioni

ISBN:

9780521671910

Condizione: Nuovo
Dimensioni: 246 x 11 x 189 mm Ø 370 gr
Formato: Brossura
Illustration Notes:51 b/w illus. 6 colour illus. 12 tables 32 exercises
Pagine Arabe: 202






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