This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function.
Emmanuel Mandonnet is currently full Professor of neurosurgery at Lariboisière hospital, University of Paris. After achieving a PhD in physics in 2000, he turned towards medical school and then residency in neurosurgery. His clinical and research activities focus on brain tumors, and especially awake surgery of gliomas. More specifically, the aim of his work is to better predict the functional cognitive impact of surgical resections and to better understand the effect of electrical stimulations at different scales (from neurons to networks).
Guillaume Herbet is currently associate Professor of neuropsychology and cognitive neuroscience at University of Montpellier’ Department of medicine and clinical neuropsychologist at Gui de Chauliac hospital’ Department of Neurosurgery. His clinical activity is led in collaboration with Pr Duffau, and mainly aims to monitor cognitive functions of patients undergoing glioma resections in awake conditions. For almost 10 years, he developed new tasks to map the functional networks underlain by the right hemisphere, in particular with respect to emotion, social and semantic cognition. Guillaume Herbet is especially interested in better understanding the mechanistic aspects of tumor-induced neural plasticity and in disentangling the role of white tracts in cognition and behavior.
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