Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose.
The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.
Section I: Basic Techniques for Individualized Therapy 1. Basic Pharmacokinetics and Dynamics for Clinicians 2. Describing Drug Behavior in Groups of Patients 3. Developing Maximally Precise Dosage Regimens for Patients - Multiple Model (MM) Dosage Design 4. Optimizing Laboratory Assay Methods for Individualized Therapy 5. Evaluation of Renal Function
Section II: The Clinical Software 6. Using the BestDose Clinical Software - Examples With Aminoglycosides 7. Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models 8. Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring 9. Optimizing Individualized Drug Therapy in the ICU 10. Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill 11. Individualizing Digoxin Therapy
Section III: Clinical Applications of Individualized Therapy 12. Optimizing Single-Drug Antibacterial and Antifungal Therapy 13. Combination Chemotherapy With Anti-Infective Agents 14. Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection 15. Individualizing Tuberculosis Therapy 16. Individualizing Transplant Therapy 17. Individualizing Dosage Regimens of Antineoplastic Agents 18. Controlling Busulfan Therapy in Children 19. Individualizing Antiepileptic Therapy for Patients 20. Individualizing Drug Therapy in the Elderly 21. The Present and Future State of Individualized Therapy
Dr. Neely has a Master's of Science Degree in Clinical and Biomedical Investigations at USC, is a Fellow and Regent in the American College of Clinical Pharmacology, a member of the Society for Pediatric Research, and he consults on the United States Food and Drug Administration Anti-infective Drug Advisory Committee. He is currently the principle investigator on two NIH-sponsored clinical projects involving the developmental aspects of voriconazole pharmacokinetics, as well as creating software tools to optimally dose voriconazole, vancomycin, and other therapeutic drugs. He mentors numerous trainees and visiting scholars, is an invited speaker worldwide, and is the author of over 80 peer-reviewed papers.