In Vivo EPR (ESR) Theory and Application

In Vivo EPR (ESR) is a textbook on this relatively new subject in biomedical electron spin resonance. While a few chapters have appeared in special topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrumentation, and aspects of biochemistry, in vitro and in vivo applications. A significant amount of detail is devoted to clinical applications and the problems and pitfalls encountered in in vivo spectroscopy and imaging.
Key Features:

-History of In Vivo EPR,
-Principles of Imaging-Theory and Instrumentation,
-Time-domain Radio Frequency EPR Imaging,
-The Measurement of Oxygen In Vivo Using In Vivo EPR Techniques,
-Potential Medical (Clinical) Applications of EPR,
-Combining NMR and EPR/ESR for In Vivo Experiments.

1 Introduction to in Vivo EPR.- 1. Aim and Scope of the Book.- 2. Rationale for in Vivo EPR.- 3. Challenges of in Vivo EPR.- 4. Types of Paramagnetic Species Observable with in Vivo EPR.- 5. Types of Instrumental Approaches Used for in Vivo EPR.- 6. Experiments with Animals.- 7. Conclusions and a Look to the Future.- 8. The Nomenclature of Biomedical EPR—Reducing the Confusion.- 9. References.- Section I. Theory and Instrumentation.- 2 Principles of in Vivo EPR.- 3 Frequency and Power Considerations for in Vivo EPR and Related Techniques.- 4 CW EPR Signal Detection Bridges.- 5 Resonators for Low-Field in Vivo EPR.- 6 Principles of Imaging.- 7 Time-Domain Radio Frequency EPR Imaging.- Section II. Biochemical Applications: Biochemistry and Biophysics.- 8 Stable Soluble Paramagnetic Compounds.- 9 Stable Particulate Paramagnetic Materials as Oxygen Sensors in EPR Oximetry: Coals, Lithium Phthalocyanine, and Carbon Chars.- 10 Packaging of Paramagnetic Materials in Oximetry and Other Applications.- 11 Spin Trapping in Vivo: Facts and Artifacts.- 12 Ex Vivo Detection of Free Radical Metabolites of Toxic Chemicals and Drugs by Spin Trapping.- 13 Chemistry and Biology of Nitric Oxide.- 14 In Vivo and in Vitro Detection of NO by EPR.- 15 The Measurement of Oxygen in Vivo Using EPR Techniques.- 16 Cardiac Applications of in Vivo EPR Spectroscopy and Imaging.- 17 Applications of in Vivo EPR Spectroscopy and Imaging in Cancer Research.- 18 Applications of in Vivo EPR Spectroscopy and Imaging to Skin.- 19 Pharmaceutical Applications of in Vivo EPR.- 20 Proton-Electron Double-Resonance Imaging (PEDRI).- 21 Combining NMR and EPR/ESR for in Vivo Experiments.- 22 Potential Medical (Clinical) Applications of EPR: Overview and Perspectives.- of Previous Volumes.

Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.