This volume provides comprehensive and up-to-date descriptions of principles and practices of in situ chemical oxidation (ISCO) for groundwater remediation. Chapters are based on a decade of intensive research, development, and demonstrations and lessons learned from commercial field applications. The intended audience includes remediation professionals, decision makers, and practicing engineers and scientists who select, design, and operate ISCO remedial systems, and researchers seeking to improve the current state-of-the-art. This volume should serve as a useful resource to assist remediation professionals in applying and developing ISCO technologies as effectively as possible.