Heparanase - Vlodavsky Israel (Curatore); Sanderson Ralph D. (Curatore); Ilan Neta (Curatore) | Libro Springer 04/2021 - HOEPLI.it


home libri books ebook dvd e film top ten sconti 0 Carrello


Torna Indietro

vlodavsky israel (curatore); sanderson ralph d. (curatore); ilan neta (curatore) - heparanase

Heparanase From Basic Research to Clinical Applications

; ;




Disponibilità: Normalmente disponibile in 15 giorni


PREZZO
194,98 €
NICEPRICE
185,23 €
SCONTO
5%



Questo prodotto usufruisce delle SPEDIZIONI GRATIS
selezionando l'opzione Corriere Veloce in fase di ordine.


Pagabile anche con 18App Bonus Cultura e Carta del Docente


Facebook Twitter Aggiungi commento


Spese Gratis

Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 04/2021
Edizione: 1st ed. 2020





Trama

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. 

Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.






Sommario

Historical background

1. Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover

2. Gene cloning/overview

3. Gene cloning/melanoma metastasis

4. Gene cloning/cancer/immune system

5. Heparin/HS modifying enzymes

 

Crystal structure/substrate specificity/gene regulation

6. Crystal structure

7. Molecular dynamics, KKDC peptide

8. Biochemistry/active site

9. Substrate specificity

10.Gene regulation, promoter/Egr1/methylation

11. SNPs - polymorphism

12. Splice variants

 

Cell & tumor biology (general functions & mode of action)

13 Exosomes/heparan sulfate/heparanase

14. Exosomes/drug resistance

15. Nuclear heparanase/transcriptional activity

 16. Non-enzymatic  functions/signal transduction/cellular trafficking/autophagy

17. Heparan sulfate/stem cells/inflammation

18. Danger signals/HS/platelet  heparanase

19. Heparanase/integrins/melanoma

 

Immune cells/immuno-modulation

20. Heparin, heparanase & selectins in cancer metastasis and inflammation

21Trans-endithelial migration, lymphocytes/neutrophils/t-cells

22 Macrophages/ dendritic cells/autoimmunity

23. Macrophages, Heparanase and the tumor microenvironment, neutralizing antibodies

24. NK cells

 

Cancer (heparanase in specic types of cancer)

25. Myeloma/inhibition/drug resistance

26. Breast cancer/pancreatic cancer/Cancer & Inflammation

27 Brain metastasis/mir-1258

28. Gastric cancer/immunization

29. Head & Neck

30. Glioma

31.Sarcoma

 

Inhibitors/clinical trials/cancer

32. Chemistry/synthesis of heparanase inhibitors PI-88, PG

33. PG series; biology. Tumor models & clinical trial

34 Chemically modified heparins/ Heparin mimetics

35. Roneparstat/small molecules/clinical trials

 

Other indications/diseases

36.IBD/inflammation & cancer/diabetes/obesity

37 immune diabetes

38. Inflammation, Sepsis/Amyloidosis

39. Kidney dysfunction

40. Fibrosis

41. Viral infection

42. Cariomyocytes/ Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy 

43. Eye research

44. Atherosclerosis, nuclear localization

45. Coagulation/tissue factor

 

Heparanase-2 (Hpa2)

46. Hpa2 gene cloning

47. UFS - urofacial syndrome; peripheral neuropathy

48. Hpa2: tumor suppressor





Autore

Israel Vlodavsky is a Professor of Cancer and Vascular Biology at Technion- Israel Institute of Technology’s Rappaport Faculty of Medicine and Technion Integrated Cancer Center (TICC). Vlodavsky’s discovery of the extracellular matrix as a reservoir for bioactive molecules provided the basis for the current appreciation of the tumor microenvironment and its significance in cancer progression and treatment. A pioneering achievement of Vlodavsky is the cloning and characterization of heparanase, the predominant enzyme that degrades heparan sulfate and fulfills important roles in tissue remodeling, cancer metastasis, angiogenesis, inflammation, diabetes, and kidney dysfunction. Through the combination of basic and translational research, Vlodavsky is the leading scientist in this area of research, offering basic insights and new treatment strategies for various cancers and other diseases. He earned his bachelor’s and Master’s degrees from The Hebrew University of Jerusalem, and Ph.D. from the Weizmann Institute, Rehovot, Israel.
 
Ralph Sanderson is the UAB Endowed Professor of Cancer Pathobiology and Director, Division of Molecular and Cellular Pathology, Department of Pathology, UAB O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham. Sanderson earned a B.S. from the University of Alabama, and a Ph.D. at the University of Alabama at Birmingham. His research focuses on determining how tumor-host cell interactions mediated by heparan sulfate and the enzyme heparanase regulate the tumor microenvironment and promote tumor progression, and to use that knowledge to design new cancer therapies.

 
Neta Ilan is a Senior Researcher at the Rappaport Faculty of Medicine and the Technion Integrated Cancer Center (TICC), Haifa, Israel. Neta earned a bachelor’s degree in Agricultural Sciences and a Master’s degree in Biotechnology from the Hebrew University of Jerusalem. Neta completed his education at the Hebrew University, with a doctorate in Animal Sciences, working on manipulation of the mammary gland of transgenic animals. He did his postdoctoral training at Yale University, focusing on tumor angiogenesis. His current research focuses on the mode of action and role of heparanase in cancer initiation, growth, and metastasis in order to address problems in the prevention, management, and treatment of cancer.








i libri che interessano a chi ha i tuoi gusti





Altre Informazioni

ISBN:

9783030345235

Condizione: Nuovo
Collana: Advances in Experimental Medicine and Biology
Dimensioni: 235 x 155 mm Ø 1359 gr
Formato: Brossura
Illustration Notes:61 Illustrations, black and white
Pagine Arabe: 885
Pagine Romane: xviii






Utilizziamo i cookie di profilazione, anche di terze parti, per migliorare la navigazione, per fornire servizi e proporti pubblicità in linea con le tue preferenze. Se vuoi saperne di più o negare il consenso a tutti o ad alcuni cookie clicca qui. Chiudendo questo banner o proseguendo nella navigazione acconsenti all’uso dei cookie.

X