Heat Shock Protein 90 In Human Diseases And Disorders - Asea Alexzander A. A. (Curatore); Kaur Punit (Curatore) | Libro Springer 11/2020 - HOEPLI.it

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asea alexzander a. a. (curatore); kaur punit (curatore) - heat shock protein 90 in human diseases and disorders

Heat Shock Protein 90 in Human Diseases and Disorders


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Lingua: Inglese


Pubblicazione: 11/2020
Edizione: 1st ed. 2019




Chapter 1. Regulatory Roles Of HSP90-rich Extracellular Vesicles

Takanori Eguchi, Kisho Ono, Kazumi Kawata, Kuniaki Okamoto and Stuart K Calderwood

Department of Dental Pharmacology and Advanced Research Center for Oral and Craniofacial Sciences

Dentistry and Pharmaceutical Sciences

Okayama University

Okayama, Japan


Chapter 2. HSP90-Based Heterocomplex As Essential Regulator For Cancer Disease

Mario D. Galigniana

Instituto de Biología y Medicina Experimental (IBYME)-CONICET & Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales

Universidad de Buenos Aires

Buenos Aires, Argentina


Chapter 3. Therapeutic Potential Of Heat Shock Protein 90 Inhibitors In Colorectal Cancer Reyhaneh Moradi-Marjaneh, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan and Majid Khazaei

Metabolic Syndrome Research Center and Cancer Research Center and Department of Modern Sciences and Technologies, Faculty of Medicine


Department of Physiology

Faculty of Medicine

Mashhad University of Medical Sciences

Mashhad, Iran


Chapter 4. Hsp90 In The Migration Of Primordial Germ Cells: A Model To Study Long-Distance Cell Migration And Perhaps Cancer?

Marie Lejong, Nathalie Vanmuylder and Stéphane Louryan

Laboratory of Anatomy

Biomechanics and Organogenesis, Faculty of Medicine

Université Libre de Bruxelles


Chapter 5. Role Of Heat Shock Protein 90 In Mammary Tumorigenesis

B.V. Sunil Kumar, Priya K. Gopal and Ramneek Verma

Department of Microbial and Environmental Biotechnology

School of Animal Biotechnology

Guru Angad Dev Veterinary and Animal Sciences University

Ludhiana, India


Chapter 6. Role Of HSP90 Inhibitors In The Treatment Of Cancer

Geraldine O’Sullivan Coyne, Cecilia Monge and Alice P. Chen

Division of Cancer Treatment and Diagnosis and Center for Cancer Research

National Cancer Institute

National Institutes of Health

Bethesda, USA


Chapter 7. p53-HSP90 Axis In Human Cancer

Amr Ghaleb and Natalia Marchenko

Department of Pathology

Stony Brook University

Stony Brook, USA


Chapter 8. HSP90 And Its Inhibitors For Cancer Therapy: Use Of Nano-delivery System To Improve Its Clinical Application

Prathap Somu and Subhankar Paul

Department of Biotechnology & Medical Engineering National Institute of Technology

Rourkela, India

Chapter 9. Hsp90 Is A Pivotal Player In Retinal Disease And Cancer

Asmaa Aboelnour, Ahmed E. Noreldin and Islam M. Saadeldin

Department of Animal Production

College of Food and Agricultural Science

King Saud University

Riyadh, Saudi Arabia


Department of Physiology, Faculty of Veterinary Medicine

Zagazig University

Zagazig, Egypt


Chapter 10. Targeting Hsp-90 Related Disease Entities For Therapeutic Development

Timothy Westlake, Mithcell Sun, Brandon C. Rosenblum, Zhengping Zhuang and Jared S. Rosenblum

Neuro-Oncology Branch, National Cancer Institute

National Institutes of Health

Bethesda, USA


Chapter 11. HSP90: A Key Player In Metal-Induced Carcinogenesis?

Abreu Pl, Ferreira LMR, Cunha-Oliveira T, Alpoim MC and Urbano AM

Department of Life Sciences and Molecular Physical Chemistry Research Unit

University of Coimbra

Coimbra, Portugal


Section II: Biomolecular Aspects of HSP90


Chapter 12. Hsp90 And Its Role In Heme-Maturation Of Client Proteins: Implications For Human Diseases

Arnab Ghosh and Dennis J. Stuehr

Department of Inflammation and Immunity

Lerner Research Institute

The Cleveland Clinic

Cleveland, USA


Chapter 13. Moonlighting Functions Of Heat Shock Protein 90

Chang Chen and Constance Jeffery

Department of Bioengineering

University of Illinois at Chicago

Chicago, USA


Chapter 14. Hsp90 As A Member Of Dicarboxylate Clamp TPR Protein Interaction Network: Implication In Human Diseases And Prospect As A Drug Target

Rajnish Kumar, Bengt Winblad and Pavel F. Pavlov

Memory Clinic

Theme Aging, Karolinska University Hospital

Huddinge, Sweden


Chapter 15. ‘Complex World’ Of Hsp90 Co-chaperone R2TP

Chrisostomos Prodromou

University of Sussex

Genome Damage and Stability Centre

Science Park Road, Brighton

Falmer, UK


Chapter 16. Functions Of SGT1, A Co-chaperone

Yohei Niikura and Katsumi Kitagawa

Greehey Children's Cancer Research Institute

Department of Molecular Medicine

UT Health San Antonio

San Antonio, USA


Chapter 17. Sti1/Hop Plays A Pivotal Role In Hsp90 Regulation Beyond Bridging Hsp70

Michael Reidy

Laboratory of Biochemistry and Genetics

National Institute of Diabetes and Digestive and Kidney Diseases

National Institutes of Health

Bethesda, USA


Section III: HSP90 in Natural Products Development


Chapter 18. Hsp90: A Target for Susceptibilities And Substitutions In Biotechnological And Medicinal Application

Athanasia Warnecke, Andreas Kirschning, Daniel Landsberg and Carsten Zeilinger

Leibniz University Hannover

Institute of Biophysic and Center of Biomolecular Drug Research Center (BMWZ)

Hannover, Germany


Chapter 19. Screening Technique For Heat Shock Protein 90 Inhibitors From Natural Products

Yue Hu, Xiao J. Zhang, Xiao T. Yang, Ying Y. Tang, Lin Y. Hu and Dong Zhu

School of Pharmacy, Nanjing University of Chinese Medicine and Jiangsu Key Laboratory for Functional Substance of Chinese Medicine and State Key Laboratory Cultivation Base for TCM Quality and Efficacy

Nanjing University of Chinese Medicine

Nanjing, China


Chapter 20. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the Celastraceae Family

Bin Peng, Ying Wang, Yu-Ting Song, Xue Zhang, Fan-Fan Cao, Li-Min Xu, Mei Jiang, Xiao-Ling Bo, Georges Uzan and Deng-Hai Zhang

Sino-French Cooperative Lab

Shanghai Gongli Hospital

The Second Military Medical University

Shanghai, China


Section IV: Clinical Aspects of HSP90


Chapter 21. Hsp90 Chaperone In Disease

Luca Ferrari and Stefan G. D. Rüdiger

Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research and Science for Life, Utrecht University

Utrecht, The Netherlands


Chapter 22. Theranostic Implications Of Heat Shock Proteins In Idiopathic Pulmonary Fibrosis

Ganapasam Sudhandiran, Divya Th


The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90.  

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.


Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.

Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 10 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

Altre Informazioni



Condizione: Nuovo
Collana: Heat Shock Proteins
Dimensioni: 235 x 155 mm Ø 1040 gr
Formato: Brossura
Illustration Notes:29 Illustrations, black and white
Pagine Arabe: 607
Pagine Romane: xi

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