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kostrzewa richard m. (curatore) - handbook of neurotoxicity

Handbook of Neurotoxicity

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Lingua: Inglese


Pubblicazione: 01/2023
Edizione: 2nd ed. 2022


This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.


Part A

1.       Cell Death Processes: Neurons and Glia

2.       Neuronal Necrosis

3.       Neuronal Apoptosis                                                                       

4.       Autophagy Pathways                                                                    

5.       Necrostatin Neuroprotection                                                                    

6.       Neuronal Necroptosis, Relation to Neurological Disorders                                                                             

7.       Multiple Cell Death Processes in Neurological Disorders                                                                

8.       Micorglia: Neuroprotective and Neurodestructive Properties                                                                       

Part B   

9.       Selective Neurotoxins                                                                                                                   

10.   Survey of Selective Neurotoxinx                                                                                               

11.   RCSN Cell System for Identifying Dopaminergic Neurotoxicity                                                                     

12.   Neurotoxicity: A complex multistage process                                                                                                                                                                                                                                      

Part C   

13.   Dopaminergic and Noradrenergic Neurotoxins                                                                  

14.   Dopamine and L-dopa as Selective Endogenous Neurotoxins                                       

15.   Dopamine D2 Receptor Supersensitivity as a non-Degenerative Neurotoxin          

16.    Trace Amine-Associated Receptor 1 (TAAR1) and Doapmine Receptor Sensitivity

17.   Dopamine Receptor Supersensitivity to Model Schizophrenia      

18.   Pathophysiology of Obsessive-Compulsive Disorder: Insights from Normal Function and Neurotoxic Effects of Drugs, Infection, and Brain Injury                                                


Richard M. Kostrzewa, Ph.D., Dr.h.c., obtained a Ph.D. (1971) in Pharmacology from the University of Pennsylvania, under the guidance of his Ph.D. advisor and mentor, Dr. David M. Jacobowitz, who became the inaugural Chief of Histopharmacology at the National Institutes of Mental Health. Dr. Kostrzewa, following career stints as Research Pharmacologist at the Veterans Administration Medical Center in New Orleans, Louisiana (1971–1975), adjunct Assistant Professor in the Department of Pharmacology at Tulane Medical School (1974–1976) and Department of Psychology at the University of New Orleans (1974–1977), and Associate Professor at the Louisiana State University Medical Center in New Orleans (1975–1978) joined the faculty of Pharmacology at the newly established Quillen College of Medicine at East Tennessee State University in Johnson City, Tennessee (Assoc. Prof./Professor), and has been a faculty member there for 45 years. Dr. Kostrzewa actively collaborated in research for 20 years with Prof. Ryszard Brus of the Silesian Medical University in Katowice, Poland, where he was Visiting Professor (1997–2003) and from which he received the Doctorate Honoris Causa (2005). In 2001, Dr. Kostrzewa was made an Honorary Member of the Polish Pharmacological Society. His research focus has remained on selective neurotoxins, with applications in the areas of nerve regeneration and sprouting, neurodegenerative disorders, dopamine receptor supersensitivity, and modeling of Parkinson’s disease, attention-deficit hyperactivity disorder, tardive dyskinesia, schizophrenia, and other neurologic disorders. He has authored and edited more than 10 books and more than 200 scientific papers, including the article “Pharmacological Actions of 6-Hydroxydopamine,” which in 1994 was designated in Current Contents as a “Citation Classic,” being one of the 400 most-cited papers at that time. Dr. Kostrzewa was co-founder with Prof. Dr. Juan Segura-Aguilar (University of Chile) of the Neurotoxicity Society, serving as its inaugural President, as the Society’s Treasurer for 10 years, and as its Secretary. Founder of the journal Neurotoxicity Research, he was its inaugural Editor-in-Chief, and he has served in that capacity for 24 years.

Altre Informazioni



Condizione: Nuovo
Dimensioni: 235 x 155 mm Ø 5347 gr
Formato: Copertina rigida
Illustration Notes:XLI, 2575 p. 296 illus., 196 illus. in color. In 3 volumes, not available separately.
Pagine Arabe: 2575
Pagine Romane: xli

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