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bawa raj (curatore); audette gerald f. (curatore); rubinstein israel (curatore) - handbook of clinical nanomedicine

Handbook of Clinical Nanomedicine Nanoparticles, Imaging, Therapy, and Clinical Applications

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Lingua: Inglese

Pan Stanford

Pubblicazione: 04/2016
Edizione: 1° edizione

Note Editore

This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosimilars and 3D nanofabrication. While bridging the gap between basic biomedical research, engineering, medicine and law, the handbook provides a thorough understanding of nano’s potential to address (i) medical problems from both the patient and health provider's perspective, and (ii) current applications and their potential in a healthcare setting.



Science at the Nanoscale: Introduction and Historical Perspective
Chin Wee Shong, PhD, Sow Chorng Haur, PhD, and Andrew T. S. Wee, PhD

Nanomedicine: Dynamic Integration of Nanotechnology with Biomedical Science
Ki-Bum Lee, PhD, Aniruddh Solanki, PhD, John Dongun Kim, PhD, and Jongjin Jung, PhD

A Small Introduction to the World of Nanomedicine
Rutledge Ellis-Behnke, PhD

Top Ten Recent Nanomedical Research Advances
Melanie Swan, MBA

The Coming Era of Nanomedicine
Fritz Allhoff, JD, PhD

What’s in a Name? Defining "Nano" in the Context of Drug Delivery
Raj Bawa, MS, PhD


Properties of Nanoparticulate Materials
Takuya Tsuzuki, PhD

Solid Drug Nanoparticles: Methods for Production and Pharmacokinetic Benefits
Andrew Owen, PhD, and Steve P. Rannard, DPhil

Design and Development of Approved Nanopharmaceutical Products
Heidi M. Mansour, PhD, RPh, Chun-Woong Park, PhD, and Raj Bawa, MS, PhD

Nanosizing Approaches in Drug Delivery
Sandip Chavhan, PhD, Kailash Petkar, PhD, and Krutika Sawant, PhD

Multilayered Nanoparticles for Personalized Medicine: Translation into Clinical Markets
Dania Movia, PhD, Craig Poland, PhD, Lang Tran, PhD, Yuri Volkov, PhD, and Adriele Prina-Mello, PhD

Nanomaterials for Pharmaceutical Applications
Brigitta Loretz, PhD, Ratnesh Jain, PhD, Prajakta Dandekar, PhD, Carolin Thiele, PhD, Yamada Hiroe, PhD, Babak Mostaghaci, PhD, Lian Qiong, MSc, and Claus-Michael Lehr, PhD

Polysaccharides as Nanomaterials for Therapeutics
Shoshy Mizrahy, MSc, and Dan Peer, PhD

The Story of C60 Buckminsterfullerene
Harold W. Kroto, PhD

Applications of Nanoparticles in Medical Imaging
Jason L. J. Dearling, PhD, and Alan B. Packard, PhD

Nanoimaging for Nanomedicine
Yuri L. Lyubchenko, PhD, DSc, Yuliang Zhang, Alexey V. Krasnoslobodtsev, PhD, and Jean-Christophe Rochet, PhD

Nanoparticles for Multi-Modality Diagnostic Imaging and Drug Delivery
Catherine M. Lockhart, PharmD, and Rodney J. Y. Ho, PhD

Magnetic Nanoparticles for Magnetic Resonance Imaging: A Translational Push toward Theranostics
Ryan A. Ortega, Thomas E. Yankeelov, PhD, and Todd D. Giorgio, PhD

First-in-Human Molecular Targeting and Cancer Imaging Using Ultrasmall Dual-Modality C Dots
Michelle S. Bradbury, MD, PhD, and Ulrich Wiesner, PhD

Atomic Force Microscopy for Nanomedicine
Shivani Sharma, PhD, and James K. Gimzewski, PhD

Atomic Force Microscopy Imaging and Probing of Amyloid Nanoaggregates
Yuri L. Lyubchenko, PhD, DSc, and Luda S. Shlyakhtenko, PhD

Image-Based High-Content Analysis, Stem Cells and Nanomedicines: A Novel Strategy for Drug Discovery
Leonardo J. Solmesky, PhD, Yonatan Adalist, MSc, and Miguel Weil, PhD

Viral Nanoparticles: Tools for Materials Science and Biomedicine
Nicole F. Steinmetz, PhD, and Marianne Manchester, PhD

Bacterial Secretion Systems: Nanomachines for Infection and Genetic Diversity
Agnesa Shala, PhD, Michele Ferraro, MSc, and Gerald F. Audette, PhD

The Vascular Cartographic Scanning Nanodevice
Frank J. Boehm

Advancements in Ophthalmic Glucose Nanosensors for Diabetes Management
Angelika Domschke, PhD


Towards Nanodiagnostics for Bacterial Infections
Georgette B. Salieb-Beugelaar, PhD, and Patrick R. Hunziker, MD

Copaxone® in the Era of Biosimilars and Nanosimilars
Jill B. Conner, MS, PhD, Raj Bawa, MS, PhD, J. Michael Nicholas, PhD, and Vera Weinstein, PhD

Doxil®: The First FDA-Approved Nanodrug—From an Idea to a Product (January 2015 Update)
Yechezkel Barenholz, PhD

Nanotechnology and the Skin Barrier: Topical and Transdermal Nanocarrier-Based Delivery
Hagar I. Labouta, PhD, and Marc Schneider, PhD

Application of Nanotechnology in Non-Invasive Topical Gene Therapy
Mahmoud Elsabahy, PhD, Maria Jimena Loureiro, MSc, and Marianna Foldvari, PhD, DPharmSci

Nanocarriers in the Therapy of Inflammatory Disease
Alf Lamprecht, PhD

Advanced 3D Nano/Microfabrication Techniques for Tissue and Organ Regeneration
Benjamin Holmes, MSc, Thomas J. Webster, PhD, and Lijie Grace Zhang, PhD

Nanomedicine for Acute Lung Injury/Acute Respiratory Distress Syndrome: A Shifting Paradigm?
Ruxana T. Sadikot, MD, and Israel Rubinstein, MD

Nanoviricides: Targeted Anti-Viral Nanomaterials
Randall W. Barton, PhD, Jayant G. Tatake, PhD, and Anil R. Diwan, PhD

Nanotechnology in Tissue Engineering for Orthopaedics
Lesley M. Hamming, PhD, JD, and Mark G. Hamming, MD

Applications of Nanomaterials in Dentistry
Karolina Jurczyk, DDS, PhD, and Mieczyslaw Jurczyk, PhD, DSc

Biomimetic Applications in Regenerative Medicine: Scaffolds, Transplantation Modules, Tissue Homing Devices, and Stem Cells
David W. Green, PhD, and Besim Ben-Nissan, PhD

Potential Applications of Nanotechnology in the Nutraceutical Sector
Shu Wang, MD, PhD, and Jia Zhang, MS

Designing Nanocarriers for the Effective Treatment of Cardiovascular Diseases
Bhuvaneshwar Vaidya, MPharm, PhD, and Suresh P. Vyas, MPharm, PhD

Carbon Nanotubes as Substrates for Neuronal Growth
Cécilia Ménard-Moyon, PhD

Polymeric Nanoparticles for Cancer Therapeutics
Mohit S. Verma, Joshua E. Rosen, Ameena Meerasa, Serge Yoffe, MEng, and Frank X. Gu, PhD

Nanotechnology for Radiation Oncology
Srinivas Sridhar, PhD, Ross Berbeco, PhD, Robert A. Cormack, PhD, and G. M. Makrigiorgos, PhD

Gold Nanoparticles against Cancer
Joan Comenge, PhD, Francisco Romero, PhD, Aurora Conill, MS, and Víctor F. Puntes, PhD

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Cancer Therapy
Melike Üner, PhD

Nanomedicines Targeted to Aberrant Cancer Signaling and Epigenetics
Archana Retnakumari, MTech, Parwathy Chandran, MTech, Ranjith Ramachandran, MSc, Giridharan L. Malarvizhi, MTech, Shantikumar Nair, PhD, and Manzoor Koyakutty, PhD

Biodegradable Nanoparticle-Based Antiretroviral Therapy across the Blood-Brain Barrier
Supriya D. Mahajan, PhD, Yun Yu, PhD, Ravikumar Aalinkeel, PhD, Jessica L. Reynolds, PhD, Bindukumar B. Nair, PhD, Manoj J. Mammen, MD, Tracey A. Ignatowski, PhD, Chong Cheng, PhD, and Stanley A. Schwartz, PhD, MD

HIV-Specific Immunotherapy with Synthetic Pathogen-Like Nanoparticles
Orsolya Lorincz, PhD, and Julianna Lisziewicz, PhD

Biomedical Engineering and Nanoneurosurgery: From the Laboratory to the Operating Room
Mario Ganau, MD, PhD, Roberto I. Foroni, PhD, Andrea Soddu, PhD, and Rossano Ambu, MD

Nanotechnology-Based Systems for Microbicide Development
Rute Nunes, Carole Sousa, Bruno Sarmento, PhD, and José das Neves, PhD

Nanotechnology-Based Solutions to Combat the Emerging Threat of Superbugs: Current Scenario and Future Prospects
Nisha C. K


Raj Bawa, MS, PhD, is president of Bawa Biotech LLC, a biotech/pharma consultancy and patent law firm based in Ashburn, Virginia that he founded in 2002. He is an inventor, entrepreneur, professor and registered patent agent licensed to practice before the US Patent & Trademark Office. Trained as a biochemist and microbiologist, he has been an active researcher for over two decades. He has extensive expertise in the pharmaceutical sciences, biotechnology, nanomedicine, drug delivery, biodefense, FDA regulatory issues, and patent law. Since 1999, he has held various adjunct faculty positions at Rensselaer Polytechnic Institute in Troy, NY, where he is currently an adjunct professor of biological sciences and where he received his doctoral degree in three years (biophysics/biochemistry). Since 2004, he has been an adjunct professor of natural and applied sciences at NVCC in Annandale, VA. He is a scientific advisor to Teva Pharmaceutical Industries, Ltd., Israel. He has served as a principal investigator of National Cancer Institute SBIRs and reviewer for both the National Institutes of Health and the National Science Foundation. In the 1990s, Dr. Bawa held various positions at the US Patent & Trademark Office, including primary examiner for 6 years. He is a life member of Sigma Xi, co-chair of the Nanotech Committee of the American Bar Association and serves on the Global Advisory Council of the World Future Society. He has authored over 100 publications, co-edited four texts and serves on the editorial boards of numerous peer-reviewed journals, including serving as a special associate editor of Nanomedicine (Elsevier) and an editor-in-chief of the Journal of Interdisciplinary Nanomedicine (Wiley). Some of Dr. Bawa’s awards include the Innovations Prize from the Institution of Mechanical Engineers, London, UK (2008), the Key Award from Rensselaer’s Office of Alumni Relations (2005) and the Lifetime Achievement Award from the American Society for Nanomedicine (2014).

Gerald F. Audette, PhD, has been a faculty member at York University in Toronto, Canada, since 2006. Currently, he is an associate professor in the Department of Chemistry and acting director of the Centre for Research on Biomolecular Interactions at York University. He received his doctorate in 2002 from the Department of Biochemistry at the University of Saskatchewan in Saskatoon, Canada. Working with Drs. Louis T. J. Delbaere and J. Wilson Quail (1995–2001), Dr. Audette’s research focused on the elucidation of the protein–carbohydrate interactions that occur during blood-group recognition (in particular during the recognition of O blood type) using high-resolution X-ray crystallography. Dr. Audette conducted his postdoctoral research at the University of Alberta (2001–2006) in Edmonton, Canada. Working with Drs. Bart Hazes and Laura Frost; his research again utilized high-resolution protein crystallography to examine the correlation between protein structure and biological activity of type IV pilins that are assembled into pili used by bacteria for multiple purposes, including cellular adhesion during infection. It was during these studies that Dr. Audette identified the generation of protein nanotubes from engineered pilin monomers. Dr. Audette also studied the process of bacterial conjugation (or lateral gene transfer) using the F-plasmid conjugative system of Escherichia coli. Current research directions include: structure/function studies of proteins involved in bacterial conjugation systems, the structural and functional characterization of several type IV pilins (the monomeric subunit of the pilus), their assembly systems, and adapting these unique protein systems for applications in bionanotechnology. Dr. Audette has previously served as co-editor- in-chief of the Journal of Bionanoscience (2007–2010), and is currently a subject editor of structural chemistry and crystallography for the journal FACETS.

Israel Rubinstein, MD, is professor of medicine at the College of Medicine, University of Illinois at Chicago, USA. He is member of the section of pulmonary, critical care, allergy and sleep medicine in the Department of Medicine, University of Illinois at Chicago. He is an attending physician at the University of Illinois Hospital and Health Sciences System and Jesse Brown VA Medical Center in Chicago. Dr. Rubinstein is also the associate chief of staff for research and development at the Jesse Brown Veterans Administration Medical Center. Prior to his appointment at the University of Illinois at Chicago, he was associate professor of medicine at the University of Nebraska Medical Center in Omaha, Nebraska, USA. Dr. Rubinstein received his medical degree from the Hebrew University-Hadassah School of Medicine in Jerusalem, Israel. He was a medical resident in Israel, fellow in respirology at the University of Toronto and a research f

Altre Informazioni



Condizione: Nuovo
Collana: Pan Stanford Series on Nanomedicine
Dimensioni: 9 x 6 in Ø 4.87 lb
Formato: Copertina rigida
Illustration Notes:73 b/w images and 211 color images
Pagine Arabe: 1708

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