A systematic survey of the players and pathways that control genome function in the mammalian cell nucleus, this book ties together recently gained knowledge from a variety of scientific disciplines and approaches. All major genomic events are dissected here: replication, recombination, repair, and transcription. A major focus is on transcriptional control, including genome-wide interactions, chromatin remodeling, tissue-specific regulation, and epigenetics. High-resolution imaging and other structural data are included throughout, for a modern view of one of the most fascinating fields in the molecular life sciences.
By way of its clear and logical structure, as well as abundant high-resolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: replication, recombination, repair, and transcription. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.
Dimensioni: 249 x 32.51 x 178 mm Ø 1262 gr
Formato: Copertina rigida
Illustration Notes:73 schwarz-weiße und 30 farbige Abbildungen, 9 schwarz-weiße Tabellen
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