Preface to the Series…
Preface…
Table of Contents…
Contributing Authors…
Part I Cytological and Histological Evaluation in Rodents
1. Amino-Cupric-Silver (A-Cu-Ag) Staining to Detect Neuronal Degeneration in the Mouse Brain: The de Olmos Technique
Rosario Moratalla, Adrián Sanz-Magro, and Noelia Granado
2. Assessment of Auditory Hair Cell Loss by Cytocochleograms
Aurélie Thomas, Thomas Venet, and Benoît Pouyatos
3. Evaluation of Cellular and Molecular Pathology in the Rodent Vestibular Sensory Epithelia by Immunofluorescent Staining and Confocal Microscopy
Alberto F. Maroto, Erin A. Greguske, Alejandro Barrallo-Gimeno, and Jordi Llorens
4. Morphometric Analysis of Axons and Dendrites as a Tool for Assessing Neurotoxicity
Rhianna K. Morgan, Martin Schmuck, Ana Cristina Grodzki, Donald A. Bruun, Lauren E. Matelski, and Pamela J. Lein
Part II Physiological Evaluation in Rodents
5. DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Rat
Thomas Venet, Aurélie Thomas, Ludivine Wathier, and Benoît Pouyatos
6. Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats following Neurotoxicant Exposures
William K. Boyes
7. Electrophysiological Assessments in Peripheral Nerves and Spinal Cord in Rodent Models of Chemotherapy-Induced Painful Peripheral Neuropathy
Susanna Park, Cynthia L. Renn, Justin G. Lees, Susan G. Dorsey, Guido Cavaletti, and Valentina A. Carozzi
Part III Behavioral Evaluation in Rodents
8. The Functional Observation Battery: Utility in Safety Assessment of New Molecular Entities
David V. Gauvin
9. Behavioral Assessment of Vestibular Dysfunction in Rats
Alberto F. Maroto, Erin A. Greguske, Meritxell Deulofeu, Pere Boadas-Vaello, and Jordi Llorens
10. Assessment of Olfactory Toxicity in Dodents
David C. Dorman and Melanie L. Foster
11. Assessment of Neurotoxicant-Induced Changes in Behavior: Issues Related to Interpretation of Outcomes and Experimental Design
Deborah A. Cory-Slechta, Katherine Harvey, and Marissa Sobolewski
Part IV Molecular Methods
12. Assessment of Neurofilament Light Protein as a Serum Biomarker in Rodent Models of Toxic-Induced Peripheral Neuropathy
Giulia Fumagallia, Guido Cavalettia, Henrik Zetterberg, and Cristina Meregallia
13. Assessing Neurotoxicant-Induced Inflammation in the Central Nervous System: Cytokine mRNA with Immunostaining of Microglia Morphology
Christopher A. McPherson and G. Jean Harry
14. Mitochondrial Stress Assay and Glycolytic Rate Assay in Microglia using Agilent Seahorse Extracellular Flux Analyzers
Gabrielle Childers and G. Jean Harry
Part V Alternative Model Organism-Based Methods
15. Assessment of Larval Zebrafish Locomotor Activity for Developmental Neurotoxicity Screening
Bridgett N. Hill, Kayla D. Coldsnow, Deborah L. Hunter, Joan M. Hedge, David Korest, Kimberly A. Jarema, and Stephanie Padilla
16. A Behavioral Test Battery to Assess Larval and Adult Zebrafish after Developmental Neurotoxic Exposure
Andrew B. Hawkey, Zade Holloway, and Edward D. Levin
17. Evaluation of Neurotoxic Effects in Zebrafish Embryos by Automatic Measurement of Early Motor Behaviors
Elisabet Teixidó, Nils Klüver, Afolarin O. Ogungbemi, Eberhard Küster, and Stefan Scholz
18. Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in C. elegans
Omamuyovwi M. Ijomone, Priscila Gubert, Comfort O. A. Okoh, Alexandre M. Varão, Leandro de O. Amara, Oritoke M. Aluko, and Michael Aschner
Part VI In Vitro Methods
19. Effects of Neurotoxic or Pro-Regenerative Agents on Motor and Sensory Neurite Outgrowth in Spinal Cord Organotypic Slices and DRG Explants in Culture
Sara Bolivar, Ilary Allodi, Mireia Herrando, and Esther Udina
20. Integrative In Vitro/Ex Vivo Assessment of Dopaminergic Neurotoxicity in Rodents using Striatal Synaptosomes and Membrane Preparations
Raúl López-Arnau and David Pubill
21. Quantification of Oligodendrocytes and Myelin in Human iPSC-Derived 3D Brain Cell Cultures (Brainspheres)
David Pamies, Megan Chesnut, Hélène Paschoud, Marie-Gabrielle Zurich, Thomas Hartung, and Helena T. Hogberg
22. Measurement of Electrical Activity of Differentiated Human iPSC-Derived Neurospheres Recorded by Microelectrode Arrays (MEA)
Kristina Bartmann, Julia Hartmann, Julia Kapr, and Ellen Fritsche
Subject Index List…
