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Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.
Table of Contents
Preface
Contributors
I. The Problem and Available Resources
1. Introduction to Evidence-Based Pathology and Laboratory MedicineAlberto M. Marchevsky and Mark Wick
. Evidence-Based Pathology: A Stable Set of Principles for a Rapidly Evolving Specialty
José Costa and Sarah Whitaker
3. What Is Best Evidence in Pathology?
Peter J. Saunders and Christopher N. Otis
4. Biostatistics 101
Robin T. Vollmer
5. Prognostication and Prediction in Anatomic Pathology: Carcinoma of the Breast as an Illustrative Model
Mark R. Wick and Alberto M. Marchevsky
6. Principles of Classification and Diagnosis in Anatomic Pathology and the Inevitability of Problem Cases
Michael Hendrickson
7. Evaluating Oncopathological Studies: The Need to Evaluate the Internal and External Validity of Study Results
Michael Hendrickson and Bonnie Balzer
8. Power Analysis and Sample Sizes in Pathology Research
Robin T. Vollmer
9. Meta-Analysis: A Statistical Method to Integrate Information Provided by Different Studies
Eleftherios C. Vamvakas
10. Decision Analysis and Decision Support Systems in Anatomic Pathology
Michael Hendrickson and Bonnie Balzer
II. Solutions Offered by Evidence-Based Pathology and Laboratory Medicine11. Evidence-Based Approach to Evaluate Information Published in the Pathology Literature and Integrate It with Personal ExperienceAlberto M. Marchevsky and Mark Wick
12. Evidence-Based Cell Pathology Re-visited: A Personal View
Kenneth Fleming
13. Development of Evidence-Based Diagnostic Criteria and Prognostic/Predictive Models: Experience at Cedars Sinai Medical Center
Alberto M. Marchevsky and Ruta Gupta
14. Evaluation and Reduction of Diagnostic Errors in Pathology Using an Evidence-Based Approach
Raouf E. Nakhleh
15. Metaanalysis 101 for Pathologists
Ruta Gupta and Alberto M. Marchevsky
16. Evidence-Based Practices in Applied Immunohistochemistry: Dilemmas Caused by Cross-Purposes
Mark R. Wick, Paul E. Swanson, and Alberto M. Marchevsky
17. Evidence-Based Pathology and Laboratory Medicine in the Molecular Pathology Era: Transition of Tests from the Research Bench into Practice
Jia-Perng Jennifer Wei and Wayne W. Grody
18. The Use of Decision Analysis Tools for the Selection of Clinical Laboratory Tests: Developing Diagnostic and Forecasting Models Using Laboratory Evidence
Ji Yeon Kim, Elizabeth M. Van Cott, and Kent B. Lewandrowski 19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic 20. Evidence-Based Pathology and Tort Law: How Do They Compare? Mark R. Wick and Elliott Foucar Index
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
Mark R. Wick and Elliott Foucar
Index
19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
José Costa and Sarah Whitaker
3. What Is Best Evidence in Pathology?
Peter J. Saunders and Christopher N. Otis
4. Biostatistics 101
Robin T. Vollmer
5. Prognostication and Prediction in Anatomic Pathology: Carcinoma of the Breast as an Illustrative Model
Mark R. Wick and Alberto M. Marchevsky
6. Principles of Classification and Diagnosis in Anatomic Pathology and the Inevitability of Problem Cases
Michael Hendrickson
7. Evaluating Oncopathological Studies: The Need to Evaluate the Internal and External Validity of Study Results
Michael Hendrickson and Bonnie Balzer
8. Power Analysis and Sample Sizes in Pathology Research
Robin T. Vollmer
9. Meta-Analysis: A Statistical Method to Integrate Information Provided by Different Studies
Eleftherios C. Vamvakas
10. Decision Analysis and Decision Support Systems in Anatomic Pathology
Michael Hendrickson and Bonnie Balzer
II. Solutions Offered by Evidence-Based Pathology and Laboratory Medicine11. Evidence-Based Approach to Evaluate Information Published in the Pathology Literature and Integrate It with Personal ExperienceAlberto M. Marchevsky and Mark Wick
12. Evidence-Based Cell Pathology Re-visited: A Personal View
Kenneth Fleming
13. Development of Evidence-Based Diagnostic Criteria and Prognostic/Predictive Models: Experience at Cedars Sinai Medical Center
Alberto M. Marchevsky and Ruta Gupta
14. Evaluation and Reduction of Diagnostic Errors in Pathology Using an Evidence-Based Approach
Raouf E. Nakhleh
15. Metaanalysis 101 for Pathologists
Ruta Gupta and Alberto M. Marchevsky
16. Evidence-Based Practices in Applied Immunohistochemistry: Dilemmas Caused by Cross-Purposes
Mark R. Wick, Paul E. Swanson, and Alberto M. Marchevsky
17. Evidence-Based Pathology and Laboratory Medicine in the Molecular Pathology Era: Transition of Tests from the Research Bench into Practice
Jia-Perng Jennifer Wei and Wayne W. Grody
18. The Use of Decision Analysis Tools for the Selection of Clinical Laboratory Tests: Developing Diagnostic and Forecasting Models Using Laboratory Evidence
Ji Yeon Kim, Elizabeth M. Van Cott, and Kent B. Lewandrowski 19. Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic 20. Evidence-Based Pathology and Tort Law: How Do They Compare? Mark R. Wick and Elliott Foucar Index
Stacy E. F. Melanson, Aileen P. Morrison, David W. Bates, and Milenko J. Tanasijevic
20. Evidence-Based Pathology and Tort Law: How Do They Compare?
Mark R. Wick and Elliott Foucar
Index
Mark R. Wick and Elliott Foucar
I
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