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Essentials of Industrial Pharmacy

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Lingua: Inglese


Pubblicazione: 05/2022
Edizione: 1st ed. 2022


Essentials of Industrial Pharmacy is an attempt to comprehensively present, in a single book, various pharmaceutical processes and equipment that are frequently used for production of pharmaceutical dosage forms, along with quality control tests of these dosage forms. Pictorial/graphical illustrations provide easier understanding of complex pharmaceutical concepts, manufacturing processes of pharmaceutical dosage forms. Since it is imperative for pharmacy students to have a clear understanding of the basic concepts used in development of drugs into suitable and stable dosage forms.

This book offers a wealth of information regarding basic aspects of pharmaceutical processes and dosage forms, in a single book, for undergraduate pharmacy students or science students  (with no pharmacy background) intended to work in the pharmaceutical Industry.


Table of Contents

1 Drying
1.1 Introduction
1.2 Important Terms used in Drying Process
1.3 The Drying Curve
1.4 End Point Detection in Drying Process
1.5 Selection of Industrial Dryers
1.6 Classification of Dryers
1.6.1 Classification on the basis of mode of energy input
1.6.2 Classification on the basis of solid handling
1.7 Reference

2 Mixing
2.1 Introduction
2.2 Mixer Selection
2.3 Mixing of liquids
2.3.1 Batch type liquid mixing
2.4 Mixing of Solids and Semisolids
2.4.1 Principle of Solid Mixing
2.4.2 Degree of Mixing
2.4.3 Segregation of Powder (Demixing)
2.4.4 Mechanism of Solid Mixing
2.4.5 Factors affecting solid mixing
2.4.6 Equipments for Solid Mixing
2.4.7 Equipments for Mixing of Semi Solids
2.6 References

3 Comminution
3.1 Introduction
3.2 Importance of Particle Size
3.3 Mechanism of Size Reduction
3.4 Factors Affecting Size Reduction
3.5 Particle Size Distribution
3.6 Particle Size Analysis
3.6.1 Microscopy
3.6.2 Sieving
3.6.3 Sedimentation
3.6.4 Conductivity Method
3.7 Size Reduction of Powder
3.7.1 Cutter mill
3.7.2 Hammer mill
3.7.3 Ball mill
3.7.4 Oscillating granulator
3.7.5 Fluid Energy Mill
3.7.6 Fitz mill
3.8 Size Reduction of Pharmaceutical Dispersions
3.8.1 Agitators
3.8.2 Mechanical Mixers
3.8.4 Homogenizers
3.8.5 Ultrasonic Devices
3.9 Size Reduction in Semisolids
3.9.1 Agitators
3.9.2 Triple Roller mill
3.9.3 Vacuum Emulsifying Mixers
3.10 References

4 Filtration
4.1 Introduction
4.2 Factors Affecting Rate of Filtration
4.3 Mechanism of Filtration
4.3 Filter Media
4.4 Filter Aid
4.5 Filtration Devices
4.5.1 Filter Leaf Assembly
4.5.2 Filter Press
4.5.3 Disc Filter Assembly
4.5.4 Rotary Drum Filter Assembly
4.5.5 Bag Filter Assembly
4.5.6 Cartridge Filter Assembly
4.6 References

5 Pharmaceutical Packaging
5.1 Introduction
5.2 Properties of Pharmaceutical Packaging
5.3 Types of Packages
5.3.1 Primary Package
5.3.2 Secondary Package
5.3.3 Tertiary Package
5.4 Common Material for Pharmaceuticals Packaging
5.4.1 Metal
5.4.2 Glass
5.4.3 Plastic
5.5 Common Packaging Techniques
5.5 References

6 Oral Emulsion
6.1 Introduction
6.2 Types of Emulsions
6.3 Theory of Emulsification
6.4. Formulation Considerations of Emulsions
6.4.1 Emulsion Type
6.4.2 Volume of the Internal Phase
6.4.3 Droplet Size
6.4.4 Viscosity
6.4.5 Preservation
6.4.6 Type and Concentration of Emulsifying Agents
6.5 Emulsion Instability
6.5.1 Cracking
6.5.2 Creaming and Sedimentation
6.5.3 Phase Inversion
6.6 Excipients Used in Emulsion
6.7 Industrial Manufacturing of Emulsions
6.8 References

7 Oral Suspensions
7.1 Introduction
7.2 Dispersed Particles in a Medium
7.3 Formulation Considerations
7.3.1 Chemical Incompatibility
7.3.2 Particle size
7.3.3 Viscosity
7.3.4 Wetting
7.3.5 Mixing
7.3.6 Size reduction and Homogenization
7.3.7 Flocculation
7.3.8 Preservation
7.4 Industrial Scale Manufacturing of Suspension
7.4.1 Direct Incorporation Method
7.4.2 Precipitation Method
7.5 Stability Study of Pharmaceutical Suspensions
5.6 References

8 Tablets and Capsules
8.1 Tablet Dosage Form
8.1.1 Excipients used in Tablets
8.1.2 Techniques for Tablet Preparation
8.1.4 Tablet Compression Machines
8.1.5 Defects in Tablets and their Remedies
8.1.6 Tablet Coating
8.2 Capsule Dosage Form
8.2.1 Types of Capsules
8.3 References

9  Oral Inhalers
9.1 Introduction
9.2 Respiratory Tract
9.2.1 Macrostructure
9.2.2 Microstructure
9.3 Mechanism of Particle Deposition
9.3.1 Impaction
9.3.2 Sedimentation
9.3.3 Diffusion
9.4 Particle Engineering
9.5 Analysis of Aerodynamic Particle Properties
9.6 Devices
9.6.1 Pressurized Metered Dose Inhalers
9.6.2 Dry Powder Inhalers
9.6.3 Soft Mist Inhaler (SMI)
9.6.4 Nebulizers
9.7 Choice of Inhaler
9.8 References

10 Topically Applied Products
10.1 Introduction
10.2 Structure of the Human Skin
10.3. Dermal and Transdermal Drug Delivery
10.3.1 Permeation Through the Skin
10.3.2 Dermal Drug Delivery (e.g., Ointments and Creams)
10.3.3 Transdermal Patches
10.3.4 Transdermal Microneedles
10.4 References

11 Sterile Products
11.1 Introduction
11.2 Parenteral Dosage Forms
11.2.1 Brief History of Parenterals
11.2.2 Types of Parenterals
11.2.3 Formulation Considerations for Parenterals
11.2.4 Manufacturing of Parenterals
11.2.5 Sterilization of Parenteral Formulations
11.3 Sterile Ophthalmic Preparations
11.3.1 Anatomy of Eye
11.3.2 Topical Ophthalmic Products
11.4 Environmental Control for Sterile Manufacturing
11.4.1 Heating Ventilation and Air Conditioning System (HVAC)
11.4.2 Classification of Cleanroom
11.4 References

12 Industrial Hazards
12.1 Introduction
12.2 Types of Industrial Hazards
12.2.1 Physical hazard
12.2.2 Chemical Hazards
12.2.3 Mechanical Hazard
12.2.4 Psychosocial Hazards
12.3 References
13 Modified Release Drug Delivery Systems
13.1 Introduction
13.2 Types of Modified Release Dosage Forms
13.2.1 Sustained Release Drug Delivery Systems
13.2.2. Gastro-Retentive Drug Delivery Systems
13.3 References

14 Novel Drug Delivery System
14.1 Introduction
14.2 Targeted Drug Delivery
14.2.1 Passive Targeting
14.2.2 Active Targeting
14.3 Nanopharmaceuticals
14.3.1 Organic nanoparticles
14.3.2 Inorganic Nanoparticles
14.4 References

15 Polymer for Biomedical Applications
15.1 Introduction
15.2. Classification of Polymers
15.2.1 Biodegradable Polymers
15.2.2 Application of Biodegradable Polymers
15.3 References

16 Biotechnology Based Drugs
16.1 Introduction
16.2 DNA Replication
16.2.1 Transcription
16.2.2 Translation
16.3 Recombinant DNA Technology
16.3.1 DNA Transfer
16.3.2 DNA sources
16.3.3 Production by Recombinant DNA Technology
16.4 Specific DNA Techniques
16.4.1 PCR Technology
16.4.2 DNA Hybridization
16.4.3 DNA and Genome Sequencing


Dr. Saeed Ahmad Khan is an Associate Professor at the Department of Pharmacy, Kohat University of Science and Technology, Pakistan and previously a lecturer at the Sarhad University of Science and Information Technology, Pakistan. Dr. Saeed Khan graduated in Pharmacy from University of Peshawar, Pakistan. He subsequently joined Abbott Laboratories (Pakistan) Limited, where he worked in solid and liquid dosage form manufacturing sections. He was a supervisor at Parke-Davis & Co. Ltd., Karachi Pakistan, for pharmaceutical production and quality management. He earned his M.S. in Chemical Engineering from Daegu University, South Korea and obtained a DAAD scholarship to pursue a Ph.D. at the Department of Pharmaceutical Technology, under the supervision of Prof. Dr. Marc Schneider, at Philipps University Marburg, Germany, where he excelled.

He was awarded the prestigious FULBRIGHT fellowship for a one-year postdoc training under the supervision of Professor Robert O. Williams (Johnson & Johnson Centennial Chair in Pharmacy, Editor-in-Chief, AAPS PharmSciTech and Division Head) at Department of Molecular Pharmaceutics and Drug Delivery, University of Texas at Austin, USA. . He has published many peer reviewed articles in well reputed journals, has a patent and has presented sessions at international conferences.

Altre Informazioni



Condizione: Nuovo
Collana: AAPS Advances in the Pharmaceutical Sciences Series
Dimensioni: 235 x 155 mm Ø 641 gr
Formato: Copertina rigida
Illustration Notes:XV, 298 p. 135 illus., 86 illus. in color.
Pagine Arabe: 298
Pagine Romane: xv

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