Epithelial—Mesenchymal Interactions in Cancer

Epithelial-mesenchymal transitions in development and tumor progression.- Regulation of scatter factor (hepatocyte growth factor) production by tumor-stroma interaction.- Regulation of HGF and HGFR gene expression.- The role of scatter factor and the c-met proto-oncogene in angiogenic responses.- Modulation of intercellular junctions of epithelia by scatter factor (hepatocyte growth factor).- The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis.- Tumor cell interactions with the vascular endothelium and their role in cancer metastasis.- Stimulation and regulation of tumor cell motility in invasion and metastasis.- Tumor-stromal cytokine interactions in ovarian neoplasms.- Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction.- Stromal-epithelial interaction in type IV collagenase expression and activation: The role in cancer metastasis.- Angiogenesis as a component of epithelial-mesenchymal interactions.- Mammary tumor fibroblasts are phenotypically distinct from non-tumor fibroblasts.- Fibroblast subpopulations as accelerators of tumor progression: The role of migration stimulating factor.