Epigenetics and Pathology Exploring Connections Between Genetic Mechanisms and Disease Expression

This title includes a number of Open Access chapters. This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactions causal relationships between genes and the environment the effects of environmental chemicals on gene expression DNA methylation The book also covers the analysis and provides models for understanding the epigenetics-pathology connection. This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

The Link Between Epigenetics and DiseaseThe Epigenetics of Host-Pathogen Interactions, Elena Gómez-Díaz, Mireia Jordà, Miguel Angel Peinado, Ana RiveroThe Molecular Mechanisms of Epigenetic Regulation, Shahram Golbabapour, Mahmood Ameen Abdulla and Maryam HajrezaeiMutation Rate and DNA Methylation in the Human Genome, Junfeng Xia, Leng Han and Zhongming ZhaoCausal Relationships in Gene-Environment Interactions, Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J Khoury and Paolo VineisLysine Acetylation in Transcriptional Programming and Metabolism, Jigneshkumar Patel, Ravi R Pathak and Shiraz MujtabaHistone Deacetylases in Epigenetic Regulation, Geneviève P Delcuve, Dilshad H Khan and James R DavieAberrant Epigenetic Silencing and Gene Expression, Jon A. Oyer, Adrian Chu, Sukhmani Brar, and Mitchell S. TurkerRNAi Silencing in Poly (ADP-Ribose) Research, Christian Blenn, Philippe Wyrsch and Felix R. AlthausMicroRNA Deregulation in Rhabdomyosarcoma and Neuroblastoma, Paolo Romania, Alice Bertaina , Giorgia Bracaglia , Franco Locatelli , Doriana Fruci and Rossella RotaEpigenetic Effects of Environmental Chemicals, Sher Singh and Steven Shoei-Lung LiDNA Sequence and Epigenome-Induced Pathologies, Richard B Meagher and Kristofer J Müssar Analysis and Models for Understanding the Epigenetics-Pathology ConnectionNext-Generation Sequencing Systems, Lin Liu, Yinhu Li, Siliang Li, Ni Hu, Yimin He, Ray Pong, Danni Lin, Lihua Lu, and Maggie LawDNA Sequencing and Epigenomics Research, Martin Hirst and Marco A. MarraPredictive Models of Gene Regulation, Sonja Althammer, Amadís Pagès, and Eduardo EyrasIssues in Understanding Epigenetics and Disease, Chen-yu Liu, Arnab Maity, Xihong Lin, Robert O Wright and David C Christiani

Kasirajan Ayyanathan received his PhD degree from the Department of Biochemistry, Indian Institute of Science, one of the premier research institutions in India. Subsequently, at Temple University School of Medicine, USA, he conducted post-doctoral research on the signal transduction by purinergic receptors, a class of G-Protein Coupled Receptors (GPCR), in erythroleukemia cancer cells. Next, he was trained as a staff scientist at the Wistar Institute, USA for almost ten years and studied transcription regulation, chromatin, and epigenetic regulatory mechanisms in cancer before becoming an Associate Professor at Florida Atlantic University (FAU). Currently he is at the Center for Molecular Biology and Biotechnology as a Research Associate Professor at FAU. He is the recipient of Chern memorial award and Howard Temin career research award. Dr. Ayyanathan is well trained in molecular biology, cell biology, and biochemistry with main focus on studying transcription factors and gene regulation. Dr. Ayyanathan has published several research articles in peer-reviewed articles.