Epigenetics and DNA Damage

Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment.

Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

1. Introduction Miriam Galvonas Jasiulionis
2. DNA damage and DNA methylation
3. DNA damage and histone modifications
4. DNA damage and histone variants
5. DNA damage and chromatin regulators
6. DNA damage and miRNAs
7. DNA damage and lncRNAs
8. DNA damage, SIRT1 and epigenetic marks
9. DNA damage, metabolic alterations and epigenetic changes
10. DNA damage, diet and epigenetic changes
11. DNA damage, epigenetics and aging
12. DNA damage, epigenetics and pluripotent stem cell differentiation
13. DNA damage, epigenetics and chronic inflammatory diseases
14. DNA damage, epigenetic alterations and immune dysfunction
15. DNA repair, epigenetics and trinucleotide repeat ataxias
16. DNA damage, epigenetics and cancer
17. Oncometabolites, epigenetic marks and DNA repair
18. Therapies inducing DNA damage
19. Epigenetic therapy
20. Therapeutic strategies combining damage induction and epigenetic alterations
21. Useful protocols to study DNA damage
22. Useful protocols to study epigenetic modifications
23. Interplay between DNA repair and epigenetics: Future directions

Dr. Miriam Galvonas Jasiulionis is a Professor at the Department of Pharmacology, in the Laboratory of Ontogeny and Epigenetics, at the Universidade Federal de São Paulo, Brazil. Her lab has investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes, to contribute to better comprehension of mechanisms involved in melanoma genesis and open avenues to develop novel therapeutic approaches. Dr. Jasiulionis has published widely in such peer reviewed journals as Clinical Epigenetics, Molecular Oncology, Frontiers in Immunology, Oncotarget, Epigenetics, and Neoplasia.