Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies.
Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.
1. Engineering solutions for generating CAR-T cells 2. Engineered microbes for cancer immunotherapy 3. Biodegradable scaffolds for priming the immune cells 4. Biomaterials and devices for immunotherapy 5. Engineered devices for tumor immune modulation 6. Microfluidic devices for cancer immunotherapy and vaccination 7. Tumor-on-a-chip devices for immunotherapy 8. Engineered 3D models for cancer immunotherapy 9. Opportunities and challenges of using nanotechnology for cancer immunotherapy 10. Stromal modulation to improve immunotherapy response in cancer 11. Mapping the tumor immune microenvironment 12. Personalized cancer immunotherapy 13. Image-guided cancer immunotherapy 14. Clinical approval process and challenges for cancer immunotherapies