Drugs, Enzymes and Receptors of the Renin-Angiotensin System Celebrating a Century of Discovery

Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the renin Drugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the renin. Chapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and unique feature of this book is that a commentary on each chapter, written by an independent peer or peers, is included to present alternative views, greater depth and a different perspective. Clinicians and researchers alike will find this volume a stimulating, and perhaps even entertaining, addition to their libraries. Husain; Ahsan Victor Chang Cardiac Research Institute,Graham; Robert M. Victor Chang Cardiac Research Institute, Australia,

Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the reninChapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and unique feature of this book is that a commentary on each chapter, written by an independent peer or peers, is included to present alternative views, greater depth and a different perspective. Clinicians and researchers alike will find this volume a stimulating, and perhaps even entertaining, addition to their libraries. .

Part I: Physiology of Angiotensin II 1. The Renin-Angiotensin System and Cardiovascular Homeostasis 2. Angiotensin II Receptors in Central Nervous System Physiology 3. Current Opinions on the Involvement of Angiotensin II in Hydromineral Balance 4. Angiotensin II Effects on Reproductive Biology: Physiology or Pharmacological Curiosity? 5. Physiological Insights Derived from Mapping the Distributions of Angiotensin Receptors Part II: Molecular Basis for Angiotensin II Receptor Structure, Function and Regulation 1. Conformational Theories on Receptor Activation from Studies of the AT1 Receptor 2. Control of Angiotensin II Action Through Receptor Regulation Part III: Elucidation of Pathophysiological Mechanisms Through ACE Inhibition, AT1 Receptor Antagonism and Gene Knockouts 1. Clinical Applications and Limitations in the use of AT1-Receptor Antagonists 2. Implications for the Pathophysiology of Hypertension and Heart Failure Derived from Clinical Experience with Drugs 3. Modifying the Renin-Angiotensin System-Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Antagonists 4.Clinical Trials of ACE Inhibitors: Pathogenetic Insights and Therapeutic Advances 5. Targeted Interruption of the Renin-Angiotensin System Part IV: Angiotensin Forming Enzymes: Biochemistry, Cellular and Molecular Biology 1. Renin Secretion: Old Concepts and New Theories 2. Understanding the Regulation of Renin Gene Expression Through in vitro and in vivo Models 3. Three-Dimensional Structure and Substrate Specificity of Renin Regulation of ACE Expression: One Gene, Two Enzymes 4. ACE in the Normal and Injured Heart: Where, What and Why? 5. Chymase: A Critical Evaluation of its Role in Angiotensin II Formation and Cardiovascular Disease 6. Kallikrein: Physiological Role in Angiotensin Formation Molecular Basis for Angiotensin II Receptor Structure, Function and Regulation Part III: Elucidation of Pathophysiological Mechanisms Through ACE Inhibition, AT1 Receptor Antagonism and Gene Knockouts Part IV: Angiotensin Forming Enzymes: Biochemistry, Cellular and Molecular Biology