This book provides a comprehensive discussion of the use of NMR spectroscopy for chiral discrimination. One goal is to show the full scope of the work that has been done in this area as a way of guiding future investigations into other potential chiral reagents for use in NMR spectroscopy. It describes the systems that have been developed and the utility of these. More importantly, the book provides a comprehensive guide for investigators who may be considering using NMR spectroscopy to determine enantiomeric excess (ee) or assign the absolute configuration of a compound under study. While the book mentions all of the available chiral systems that have been reported in the literature for use in NMR spectroscopy, it focuses primarily on the systems that are commercially available. The book catalogs the range of compounds for which different reagents have been shown to be effective, and the extent to which they successfully discriminate the compounds being studied. This allows comparisons of the reagents and enables investigators to make recommendations on which reagents are most likely to be effective for particular types of compounds. Throughout the book, where appropriate, the author provides experimental strategies for using the reagents that are likely to improve the quality of results.
