Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules The Shape of Organic Synthesis to Come

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

1. Microbial Fraction Library: A Screening Source for Drug Discovery

Toshiaki Sunazuka, Tomoyasu Hirose and Satoshi Omura

4. Synthetic Approaches on the Pluramycin-class Antibiotics
Yoshio Ando, Kei Kitamura, Takashi Matsumoto and Keisuke Suzuki

5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II
Juri Sakata and Hidetoshi Tokuyama

6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis
Tohru Oishi

7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications
Yuichi Kobayashi and Miwa Shimoda

8. Total Synthesis of Ingenol
Tyler F. Higgins and Jeffrey D. Winkler

9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids
Yuichi Kobayashi and Masao Morita

12. Exploring bioactive marine natural products and identification of their molecular targets
Masayoshi Arai

13. Target protein chemical modification
Hiroyuki Nakamura

14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes
Suguru Yoshida and Takamitsu Hosoya