Current Developments in Solid State NMR Spectroscopy

Why to apply solid-state NMR? - By now, we should have learned that NMR is mainly used for the study of molecules in solution, while x-ray diffraction is the method of choice for solids. Based on this fact, the two recent 'NMR-Nobelprizes' went indeed into the liquid phase: my own one eleven years ago, and particularly the most recent one to Kurt Wuthrich. His prize is beyond any doubts very well justified. His contribution towards the study of biomolecules in solution, in their native (or almost native) environment is truly monumental. We all will profit from it indirectly when one of our future diseases will be cured with better drugs, based on the insightful knowledge gained through liquid-state NMR. Two fields of NMR are still left out of the Nobel Prize game: magnetic reso­ nance imaging (MRI) and solid-state NMR. The disrespect for MRI in Stockholm is particularly difficult to understand; but this is not a subject to be discussed at the present place. Solid-state NMR is the third of the three great fields of NMR, powerful already today and very promising for the near future.

Invited Reviews.- Dipolar and Scalar Couplings in Solid State NMR of Quadrupolar Nuclei.- Multiple-Quantum Magic-Angle Spinning: High-Resolution Solid State NMR Spectroscopy of Half-Integer Quadrupolar Nuclei.- Cross-Polarisation Applied to the Study of Liquid Crystalline Ordering.- Contributions.- Improved Proton Decoupling in NMR Spectroscopy of Crystalline Solids Using the SPINAL-64 Sequence.- The Flexibility of SIMPSON and SIMMOL for Numerical Simulations in Solid- and Liquid-State NMR Spectroscopy.- Residual Dipolar Couplings in 31P MAS Spectra of PPh3 Substituted Cobalt Complexes.- Potential and Limitations of 2D 1H-1H Spin-Exchange CRAMPS Experiments to Characterize Structures of Organic Solids.