Current Controversies in Bone Marrow Transplantation

Leading transplant physicians critically review and interpret twenty-one key clinical challenges in bone marrow/hematopoietic cell transplantation, and offer their best personal recommendations for treatment. Topics range from transplant strategies to complications of bone marrow transplantation, including a discussion of the indications, benefits, and the risks for a variety of leukemias, lymphomas, and solid tumors. The authors debate such contentious issues as the appropriateness of transplants in older patients, how many stem cells are sufficient for engraftment, and the pros and cons of umbilical cord blood transplantation. Up-to-date and clinically focused, Current Controversies in Bone Marrow Transplantation offers clinical oncologists, hematology/oncology fellows in training, and residents in internal medicine today's best ready reference and management guide for all their critical oncologic problems arising from the use of bone marrow/stem cell transplantation.

I. Transplant Strategies.- 1 How Many Stem Cells Are Sufficient for Engraftment?.- 2 Is Bone Marrow Transplantation Appropriate in Older Patients?.- 3 What Is an Accurate Risk/Benefit Ratio for Umbilical Cord Cell Transplantation in Children and Adults?.- 4 Are Busulfan-Based Preparative Regimens Equivalent, Worse, or Better than Total Body Irradiation Regimens?.- 5 Is Total Body Irradiation Necessary in Bone Marrow Transplantation for Pediatric ALL?.- II. Transplantation for Hematologic Malignancies.- 6 Stem Cell Transplantation for Chronic Myeloid Leukemia: Indications and Timing.- 7 Should All Adult Patients with Acute Lymphoblastic Leukemia in First Remission Undergo Allogeneic Bone Marrow Transplantation?.- 8 What Is the Curative Potential of Refractory Leukemia with Related and Unrelated Allogeneic Transplants?.- 9 What Is the Role of Autologous Stem Cell Transplantation for Leukemia?.- 10 Autologous Transplantation for Hodgkin’s Disease: Who Benefits?.- 11 Hematopoietic Stem Cell Transplantation for Mantle Cell Lymphoma.- 12 Is Autologous Transplantation for Non-Hodgkin’s Lymphoma Underutilized?.- III. Transplantation for Solid Tumors.- 13 Do Patients Benefit from Autotransplants for Advanced Ovarian Cancer?.- 14 What Is the Optimal Timing of Autologous Transplantation for Metastatic Breast Cancer?.- 15 Should All Patients with Inflammatory Breast Cancer Undergo Autologous Stem Cell Transplant?.- 16 High-Dose Chemotherapy with Stem Cell Rescue for Germ Cell Cancer?.- IV. Complications of Transplantation.- 17 Graft-vs-Host Disease: Has Any Progress Been Made in the Past Decade?.- 18 Veno-occlusive Disease of the Liver: Does Anything Really Work?.- 19 Myelodysplasia and Acute Leukemia Following High-Dose Chemotherapy.- 20 Can Aspergillus Infections Be Preventedin Allogeneic Bone Marrow Transplant Recipients?.- 21 Prevention of Cytomegalovirus Infection After Allogeneic Bone Marrow Transplantation.