Historical Overview Kunio Doi Computer-Aided Detection and Diagnosis in Breast ImagingDetection and Diagnosis of Breast Masses in Mammography Nico KarssemeijerDetection and Diagnosis of Microcalcifications in Mammography Hao Jing, Issam El Naqa, and Yongyi YangDetection and Diagnosis of Breast Mass in Digital Tomosynthesis Heang-Ping ChanAssessment of Breast Density Sir Michael Brady, Ralph Highnam, and Nico KarssemeijerCase-Based CAD Systems in Breast Imaging Georgia D. Tourassi and Maciej A. MazurowskiMultimodality CAD Systems for Breast Cancer Karen Drukker and Charlene A. Sennett Computer-Aided Detection and Diagnosis in Chest and Abdominal ImagingDetection of Lung Nodules in Chest Radiography Bram van GinnekenDetection and Diagnosis of Lung Nodules in Thoracic CT Qiang LiDetection and Diagnosis of Interstitial Lung Disease Shigehiko Katsuragawa, Takayuki Ishida, Kazuto Ashizawa, and Yoshikazu UchiyamaMeasurement of Change in Size of Lung Nodules Anthony ReevesPublic Lung Image Databases Samuel G. Armato IIIDetection and Diagnosis of Colonic Polyp in CT Colonography Jerome Zhengrong Liang Emerging Computer-Aided Detection and DiagnosisDetection and Characterization of Brain Tumor Walter G. O’Dell, Robert Ambrosini, Anitha Priya Krishnan, Mathews Jacob, and Delphine DavisDetection of Cerebrovascular Diseases Yoshikazu Uchiyama and Hiroshi FujitaDetection of Pulmonary Embolism Chuan Zhou and Heang-Ping ChanDetection of Eye Diseases Chisako Muramatsu and Hiroshi FujitaDetection and Diagnosis of Prostate Cancer in MR Pieter Vos, Geert Litjens, and Henkjan HuismanDetection of Bone Metastasis in Bone Scan Junji ShiraishiIntegration of CAD and PACS Brent J. Liu, Anh Le, and H.K. Huang Assessment and Clinical Utility of Computer-Aided Detection and DiagnosisMethodologies for the Assessment of CAD Systems Yulei JiangClinical Utility of CAD Systems for Breast Cancer Jocelyn A. Rapelyea and Rachel F. BremClinical Utility of CADe for Screening Mammography: A European Perspective Maureen G.C. Gillan and Fiona J. GilbertClinical Utility of CAD Systems for Lung Cancer Matthew T. FreedmanClinical Utility of CADe Systems for Colon Cancer Farid Dahi and Abraham H. DachmanFuture Perspectives: CAD to Quantitative Image Biomarkers, Phenotypes, and Imaging Genomics Maryellen L. Giger Index