Complex Carbohydrates in Health and Disease

This book provides latest insights into the clinical significance of glycans, the role that glycans play in the etiology and for the course of inborn and acquired diseases and new glycan-based therapeutics and vaccines. Furthermore, the book provides highly topical insights into the analysis and synthesis of complex carbohydrates, and outlines why proper glycosylation is a key factor for the design and the manufacturing of therapeutic antibodies, other therapeutic glycoproteins and vaccination.

Part I Synthesis of Complex Carbohydrates and Carbohydrate-based Drugs.- Chemical Synthesis of Complex Carbohydrates.- Synthesis of Sulfated Carbohydrates Glycosaminoglycans.- Activity-Based Profiling of Retaining Glycosidases in Disease Diagnosis and Their Application in Drug Discovery.- Part II Analytical Methods of Complex Carbohydrates.- Advanced Mass Spectrometry Techniques for the Characterization of Carbohydrates.- The Road Toward Nanopore Sequencing of Glycosaminoglycans.- Decrypting Glycosaminglycan Sulfation Code with Computational Approaches.- Part III Biological Functions & Medical Relevance.- Glycosylation in Stem Cell Biology.- Role of Antibody Glycosylation in Health, Disease and Therapy.- Diagnostic and Therapeutic Approaches in Congenital Disorders of Glycosylation.- Glycosylation in Cancer.