TABLE OF CONTENTS
DISCLAIMER 6
FOREWORD 7
PREFACE 8
SUMMARY 10
1. INTRODUCTION 17
2. ABOUT THE PROGRAM 18
Energy Production 21
Back To The Program 32
The Importance of Antioxidants 33
3. OMEGA-3 FATTY ACIDS (Prong-1) 47
Details of Oxidized LDL and Atherosclerosis Production 51
Fish Oil Omega-3s as an Anti-inflammatory 54
More Properties of Fish Oil 66
Summary of Cumulative Data 70
4. NITRIC OXIDE (Prong-2) 75
The “Universal Messenger” 77
Detoxification and the Urea Cycle 89
Nitric Oxide Production 92
Beet Root Powder 99
L-Arginine 100
L-Citrulline 105
L-Carnitine 109
The Anti-Atherosclerotic Molecule 110
An Anti-Inflammatory Molecule 113
Erectile Dysfunction 115
An Antioxidant Molecule 116
Heart Failure 117
Nitric Oxide in the Nervous System 124
The Dark-Side of Nitric Oxide 129
Summary 133
5. OXIDATIVE STRESS REDUCTION (Prong-3) 138
Reduce Mitochondrial Dysfunction 142
Oxidative Stress 150
Markers of Oxidative Stress 153
Aldehydes: Oxidative stress and ROS production vs. Alpha-Lipoic Acid, as Modeled in Diabetes 155
Oxidative Stress in Cardiovascular Diseases 159
Oxidative Stress I: Biology and Cardiovascular Disease 168
Oxidative Stress II: Impact on the Heart and Vasculature 170
Oxidative Stress III: Cardiovascular Risk of Obesity, Diabetes, Smoking, and Pollution 175
Oxidative Stress and Aging 176
Homocysteine 186
Folic Acid (Vitamin B9) 191
Tryptophan 192
Oxidative Stress and Autonomic Neuropathy, Type II Diabetes as a Model 196
Application in Bipolar Disease 221
Application in Heart Failure 223
Application in Fatty Liver Disease 226
Application in Mast Cell Activation Syndrome and Food Allergies 228
Preventing the Dark-Side of Nitric Oxide 232
6. MEDITERRANEAN DIET (Prong-4) 236
Disease and the Mediterranean Diet 239
Endothelial Function and the Mediterranean Diet 247
Polyphenols and the Mediterranean Diet 249
The Mediterranean Diet: What To Expect 250
Health Benefits of Olive Oil 253
The Power of the Grape 256
The Incredible Whole Wheat Grain 258
Resveratrol 262
Antioxidant Effects 263
Mediterranean Diet Summary 266
Alcohol Consumption 273
7. EXERCISE (Prong-5) 276
Exercise and the Nervous System 281
Antioxidant Effects 286
Exercise and Endothelial Function 288
Exercise and Physical Activity 292
8. PSYCHOSOCIAL STRESS REDUCTION (PRONG-6) 305
Hypothalamus-Pituitary-Adrenal Axis Connects Brain and Body 307
The Nervous System’s Brain-Body Connections 314
Modulation of Parasympathetic and Sympathetic Input to the Heart 318
Emotion and Sudden Arrhythmic Death 322
Emotions Modulate P&S Activity 327
Stress, Emotions, The Vagus Nerve, and Inflammation 330
Lateralization of Emotions and P&S Responses 331
The Brain-Heart Connection 334
Dentistry is Also Connected 337
The Vagus Nerve 339
The Brain-Gut Connection 344
Dynamic Parasympathetic Excess 345
Some Comments on Adrenal Fatigue 349
Reducing Stress is an Antioxidant 350
9. Mind-body wellness program benefits 357
Contra-Indications or Interactions 357
Alpha-Lipoic Acid Interactions 357
Coenzyme Q-10 Interactions 358
L-Arginine Interactions 358
L-Carnitine Interactions 358
L-Citrulline Interactions 359
Beet Root Extract (Nitric Oxide Supplement) Interactions 359
Lysine Interactions 359
Folic Acid Interactions 359
Omega-3, Fish Oil Interactions 359
Pharmacology and “Functional Medicine” are Complimentary 360
Cannabidiol (Marijuana) 361
B-Vitamins 362
Questionnaires 364
Compass 31 Questionnaire 366
SF-36 Questionnaire 370
Nottingham Health Profile 377
Simplified Autonomic Questionnaire 379
Questionnaire on Hypermobility Syndromes (EDS and Related Disorders) 380
Dysautonomia Drugs Taken In Past Or Present 383
Composite Autonomic Scoring Scale (CASS) 384
Autonomic Neuropathy Scoring 385
Supplements and Nutraceuticals Help to Improve Pharmacology 386
Antioxidant Treatment and Atrial Fibrillation 388
Anxiety 389
Anxiety and Depression 394
Neurofeedback 399
Atherosclerosis 401
Autonomic Dysfunction and Small Fiber Neuropathy and Their Measurements 401
Breast Cancer, Oxidative Stress, and Cardiovascular Disease 419
Chronic Fatigue Syndrome 420
Persistent Fatigue 423
Congestive Heart Failure 427
Fibromyalgia 428
Hypertension 430
Hypertension Secondary to Parasympathetic Excess 430
Hypertension Secondary to Orthostatic Dysfunction 432
Migraine Headaches 433
Mitochondrial Dysfunction and Neurodegenerative Disorders 436
Post-Traumatic Stress Disorder 449
Telomere Length, Longevity, Fish oils, and Antioxidants 455
Summation 460
Frequently Asked Questions 461
The P&S (Autonomic) Nervous Systems 461
Dysfunction of the P&S Nervous Systems 465
Tests of the P&S Nervous Systems and for Autonomic (P&S) Dysfunction 469
Lightheadedness (“Dizziness”) Due to Autonomic Dysfunction 472
Diseases that Result from Dysfunction of the P&S (Autonomic) Nervous Systems 482
Mitochondria and Mitochondrial Disorders 488
REFERENCES 491
