INTRODUCTION Progress of Food-Based Dietary Guidelines around the Globe; Yasmine Probst, Rebecca Thorne, and Jane O’Shea Clinical Perspective of Ayurceuticals: Challenges and Opportunities for Global Health and Wellness; Namyata Pathak, Hiteshi A. Shah, and Ashok Vaidya Functional Foods and Nutraceuticals: Potential Role in Human Health; Chunling Wang and Song Li The Clinical Trial Barriers in Functional Foods and Nutrition; Rajshri Roy SCIENCE UNDERPINNING HEALTH BENEFITS Dual Function of Food Factors as Pharmacological Molecules; Tetsuya Konishi Anti-Inflammatory and Chemopreventive Potentials of Citrus Auraptene; Akira Murakami Food Functions Preventing Muscle Atrophy; Junji Terao, Rie Mukai, Yui Yamashita, Arisa Ochi, Shohei Kohno, Katsuya Hirasaka, and Takeshi Nikawa Effects of Nutraceuticals on Metabolic Syndromes; Asim K. Duttaroy Cardioprotective Food Function as Underpinning Strategy for Disease Prevention: Dietary Antioxidants in Diabetic Cardiac Complications; Kenichi Watanabe, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Kenji Suzuki, and Hirohito Sone Clinical Application of Antiaging Food Factors in Functional Foods; Akira Kubo and Fumi Nihei PROBLEMS AND CHALLENGES TO INDUSTRIES, CONSUMERS, AND POLICY MAKERS Maximizing the Survival of Probiotic Bacteria in Food to Improve Their Potential Health Benefit; Namrata Taneja, Derek Haisman, and Shantanu Das Drug–Dietary Supplement Interactions; Noriaki Yohkoh Journey from Pharmaceuticals to Food: Role of Evidence-Based Approach; R.B. Smarta Heme Oxygenase-1 Induction Inhibits Intestinal Inflammation: Role of Food Factors; Yuji Naito, Tomohisa Takagi, Akihito Harusato, Yasuki Higashimura, and Toshikazu Yoshikawa INNOVATION VERSUS REGULATION Regulatory Framework of Functional Foods in Southeast Asia; Tee E. Siong Health Claims Regulation and Scientific Substantiation of Functional Foods and the International Comparison; Toshio Shimizu In Pursuit of Claims: What Works, What Does Not, and Why; Josephine M. Balzac and George A. Burdock Clinical Research—History of Regulations: A Global Perspective; Kappillil Anilkumar and K.I. Anitha FARM TO CLINIC APPROACH/FUNCTIONAL ASPECTS OF FOOD FACTORS Role of Seed to Patient Model in Clinically Proven Natural Medicines; Andrea Zangara and Dilip Ghosh Innovation in the Food Industry: Industry–Academia Partnership; Amit Taneja, Anwesha Sarkar, and Shantanu Das Curcumin for Prevention and Treatment of Chronic Diseases: An Overview of the Clinical Studies and Evidence-Based Support; Myriam Hinojosa and Bharat B. Aggarwal Human Clinical Trial for Nutraceuticals and Functional Foods; Chin-Kun Wang Clinical Outcomes, Safety, and Efficacy of Chinese Herbal Medicines; Daniel Roytas FUTURE TRENDS Traditional Foods and Their Values for Health and Wellness on Evidence-Based Approach; V. Prakash, M.A. Alwar, and M.A. Lakshmithathachar Impact of Personalized Nutrition on Public Health; Lynnette Ferguson, Karen Bishop, and Nishi Karunsinghe Effects of Ginger on Metabolic Syndrome: A Review of Evidence; Srinivas Nammi, Yu-Ting Sun, and Dennis Chang Local Food Futures and Healthy Communities: Role of Sustainable Practices; Sumita Ghosh Oriental Traditional Philosophy and Food Function; Young Rok Seo and Yeo Jin Kim Ayurnutrigenomics: Traditional Knowledge-Inspired Approach toward Personalized Nutrition; Parikshit Debnath, Subhadip Banerjee, and Pratip Kumar Debnath