Carotid Disease The Role of Imaging in Diagnosis and Management

Stroke is a major cause of morbidity and mortality, with carotid disease representing an important contributory risk factor. This book is about the pathogenesis and management of carotid disease with specific focus on the role imaging has to play in the early recognition of symptomatic and asymptomatic disease as well as the treatment of the developed condition. Technological advances in imaging modalities now allow detailed analysis of the disease progression, the prediction of critical events leading to a stroke, as well as the identification of the most effective surgical or other interventional treatments. This book should be read by neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists involved in the care of patients with carotid disease, and also by researchers involved in the development of new therapeutic techniques and drugs.

Dedication; Abbreviations; Introduction Henry J. M. Barnett; 1. Pathology of carotid artery atherosclerotic disease Renu Virmani, Allen Burke, Elena Ladich and Frank Kolodgie; 2. Epidemiology of carotid artery atherosclerosis Christopher O'Donnell; 3. Genetics of carotid atherosclerosis Stephen Rich and Donna Arnett; 4. Haematological processes in emboli formation Alison Goodall and Greg McMahon; 5. Medical treatment for carotid stenosis Matthew Giles and Peter Rothwell; 6. Surgical management of symptomatic carotid disease: carotid endarterectomy and extracranial-intracranial bypass Jonathan Brisman and Marc Mayberg; 7. Surgery for asymptomatic carotid stenosis Stella Vig and Alison Halliday; 8. Interventional management of carotid disease Andrew Clifton; 9. Conventional carotid Doppler ultrasound Gregory Moneta; 10. Conventional digital subtraction angiography for carotid disease Jean Marie U-King-Im and Jonathan Gillard; 11. Magnetic resonance angiography of the carotid artery Martin Graves, Jean Marie U-King-Im and Jonathan Gillard; 12. Computed tomographic angiography of carotid artery stenosis Paul Nederkoorn, Charles Majoie and J. Stam; 13. Cost-effectiveness analysis for carotid imaging Jean Marie U-King-Im, William Hollingworth and Jonathan Gillard; 14. Morphological plaque imaging Chun Yuan and Tom Hatsukami; 15. CT of the plaque Thomas de Weert, Mohamed Ouhlous, Marc van Sambeek and Aad van der Lugt; 16. Assessment of carotid disease with ultrasound Stephen Meairs; 17. Intravascular ultrasound Gaston Rodriguez-Granillo and Patrick Serruys; 18. Image post-processing William Kerwin, Dongxiang Xu and Fei Liu; 19. Nuclear imaging for the assessment of patients with carotid artery atherosclerosis John Davies and Peter Weissberg; 20. USPIO - enhanced MR imaging of carotid atheroma Simon Howarth, Tjun Tang, Martin Graves, Rikin Trivedi, J. Harle and Jonathan Gillard; 21. Gadolinium enhanced plaque imaging William Kerwin; 22. Carotid magnetic resonance direct thrombus imaging Alan Moody; 23. The proximal carotid arteries - image-based computational modelling X. Xu and Nick Wood; 24. Mechanical image analysis using finite element method Tjun Tang, Chun Yang and Chun Yuan; 25. Transcranial Doppler monitoring Michael Gaunt; 26. MR and CT perfusion Jeroen van der Grond and Matthias van Osch; 27. Near infrared spectroscopy in carotid endarterectomy Pippa Al-Rawi and Peter Kirkpatrick; 28. Single photon emission computed tomography (SPECT) Kuniaki Ogasawara; 29. Monitoring carotid interventions with Xenon CT H. Yonas and A. Carlson; 30. Vascular imaging and the clinical development of new pharmaceuticals James Revkin and David Lester; 31. Monitoring pharmaceutical interventions with conventional ultrasound (IMT) John Crouse; 32. Monitoring pharmaceutical interventions with IVUS Stephen Nicholls, Steven Nissen and Murat Tuzcu; 33. Monitoring of pharmaceutical interventions: MR plaque imaging Tom Hatsukami; 34. Molecular imaging of carotid artery disease James Rudd, Michael Lipinski, Fabien Hyafil and Zahi Fayad; 35. Future technical developments Brian Rutt and John Ronald.

Stroke is a major cause of morbidity and mortality, with carotid disease representing an important contributory risk factor. This book is about the pathogenesis and management of carotid disease with specific focus on the role imaging has to play in the early recognition as well as treatment of the developed condition.

Jonathan Gillard is a Reader in Neuroradiology in the University of Cambridge, and an Honorary Consultant Neuroradiologist at Addenbrooke's Hospital.
Martin Graves is Consultant Clinical Scientist in the Departments of Radiology and Medical Physics at Cambridge University Hospitals NHS Foundation Trust.
Thomas Hatsukami is a Professor of Vascular Surgery at the University of Washington School of Medicine in Seattle, Washington.
Chun Yuan is a Professor of Radiology at the University of Washington, Seattle, Washington.