Cardiovascular Regenerative Medicine Tissue Engineering and Clinical Applications

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. 

The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine.

Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Christopher W. Anderson, Jiesi Luo, Lorenzo R. Sewanan, Mehmet Kural4, Muhammad Riaz, Jinkyu Park, Yan Huang, Laura E. Niklason, Stuart G. Campbell, Yibing Qyang

Chapter 2. Phenotypic Screening of iPSC-derived Cardiomyocytes for Cardiotoxicity Testing and Therapeutic Target Discovery

Arne A.N. Bruyneel, Tyler Muser, Vaidya Parthasarathy, Dries Feyen, Mark Mercola

Chapter 3. Decellularized extracellular matrix-based cardiovascular tissue engineering

Kristin M. French, Michael E. Davis

Chapter 4. 3D bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks

Chapter 5. Nano-biomaterial Advances in Cardiovascular Tissue Engineering

Michael J. Hill, Morteza Mahmoudi, Parisa P.S.S. Abadi

Chapter 6. Bioengineering 3D Cardiac Microtissues Using Bioassembly

Longjun Gu, Jinghan Feng, Donghui Zhang, Pu Chen

Chapter 7. From bench to clinic; Translation of cardiovascular tissue engineering products to clinical applications

Y. Joseph Woo, Amanda N. Steele

Chapter 8. Cardiac patch-based therapies of ischemic heart injuries

Wuqiang Zhu, Danielle Pretorius, Jianyi Zhang

Chapter 9. Cell-Based Cardiovascular Regenerative Therapies

Ray P. Prajnamitra, Yuan-Yuan Cheng, Li-Lun Chen, Patrick C.H. Hsieh

Chapter 10. Injectable Hydrogels to Treat Myocardial Infarction

Miranda D. Diaz, Karen L. Christman

Chapter 11. Regenerative Medicine for the Treatment of Congenital Heart Disease

Dzilic E., Doppler S., Lange R., Krane,

Chapter 12. Cardiovascular Regenerative Medicine: Challenges, perspectives, and future directions

Sean M Wu, Vahid Serpooshan

Vahid Serpooshan, PhD

Wallace H. Coulter Department of Biomedical Engineering

Department of Pediatrics

Emory University and Georgia Institute of Technology

Children’s Healthcare of Atlanta (CHOA)