1. The nature and origins of cancer
Cancer as a family of diseases coming from normal cells using normal cell traits in abnormal waysCancer as a developmental process
Organization / taxonomy of the neoplasias/ terminology
2. Principles of cancer initiation, promotion and progression
Mutation, growth, clonal heterogeneity
Principles of cancer pathology: form and function and deviation from normal
Key concepts of invasion and metastasis
3. Behavioral hallmarks of cancer
Key behavioral traits that allow cancer cells to outcompete normal cells
Molecular basis of these key behaviorsCancer as an evolutionary system
Caner as a complex adaptive system
4. History of cancer – how did we get here?
Major advances in cancer biology, etiology, and treatment - foundations for current thinking and present day practice
5. Who gets cancer and why?
Cancer epidemiology worldwide
Causal risk factors
Non-causal risk factors
Why do it?
What does it take?What works and what are the recommendations?
7. Diagnosis and Assessment
Detection and diagnosis
Classification: type, grade, stage, molecular features
Prognostic factors, predictive factors and treatment planning
8. Localized treatment of cancer
Principles and types of oncologic surgeryPrinciples and types of radiation therapy
Other ablative therapies
9. Systemic therapy
Immunotherapies: (+CAR-T genetic engineering) current reality, future vision
Therapy as selective pressure and the emergence of resistance
Principles of therapy: efficacy, toxicity; cost-benefit
10. End of Life Issues: Personal and Medical
Palliative care: what it is and how it is used
Overuse of therapy at end of life
Hard decisions: when to stop treatment
11. Development of new cancer therapies: evolution and revolution
The ethical, economic, and scientific aspects of translational cancer research
The evolution of clinical trials
Cancer and the law: Right to Die; Right to try
Cancer as big business
Economics of cancer care delivery: Who pays and for what? Who decides?
Carolyn Compton, MD, PhD, FCAP
Professor of Life Sciences, Arizona State University
Barrett Honors Faculty, Arizona State University
Professor of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine
Adjunct Professor of Pathology, Johns Hopkins Medical Institutions
CMO, National Biomarker Development Alliance
Tempe, AZ 85281
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