Contents
Preface
CHAPTER 1: OUTLINE OF ANATOMY/PHYSIOLOGY OF SKELETAL TISSUES
1. Structure and Physiology of Skeletal Tissue
1.1 Bone tissue 1.2 Bone cells 1.3 Bone tissue organization 1.4 Normal bone development 1.5 Types of skeletal tissues 1.6 Bone and cartilage as skeletal tissues 1.7 Functions of bone in the skeleton 1.8 Origin and dynamic functions of the skeleton and their origins 1.9 Ultrastructure of cells of the skeleton 1.10 Cells of skeleton derived from neural crest 1.11 Fibroblasts, fibrocytes and myofibroblasts in the skeleton 1.12 Monocytes, macrophages and histiocytes 1.13 Chondroblasts and chondrocytes 1.14 Osteoblasts, osteocytes and osteoclasts 1.15 Smooth muscle cells 1.16 Striated skeletal muscle cells 1.17 Lipoblasts and lypocytes 1.18 Angioblasts, vascular endothelium, pericites
1.19 Synovium
1.20 Mast Cells
1.21 Cells of neural crest origin
CHAPTER 2: TUMORS OF THE MUSCULOSKELETAL SYSTEM
2.1 Terminology
2.2 Abnormal growths discussed vs skeletal tumors
2.3 Benign vs malignant bone tumors
2.4 Cellular features: metaplasia and anaplasia
2.5 Tumor progression: last phase in tumor development
2.6 Predisposing conditions and genetic predisposition
2.7 Tumor site of origin defines tumor categories for osteosarcoma:
2.7.1 Periosteal origin: Periosteal, Parosteal and Surface osteosarcomas
2.7.2 Medullary origin: Intramedullary (syn, Intracortical)
2.8 Introduction to tumors of bone
2.9 WHO classification scheme for domestic animal bone tumors
2.10 Tumors of bone in animals: categories, frequency and clinical behavior
2.11 Benign tumors of bone
2.11.a. Osteoma: Clinical, radiographic, CT, MRI, and microscopic features
2.11.b. Osteoblastoma: Uncommon but features are described
2.11.c. Myxoma of jaw: Uncommon; clinical and histologic features are
described
2.11.d. Osteochondroma: Growth plate dysplasia; structural features are
described
2.11.e. Feline osteochondromatosis: C-retroviral periosteal progressive
growth
2.11.f. Chondroma of bone: Periosteal nodule with clinical & structural
features
2.11.g. Hemangioma of bone: Medullary vascular lesion with features
described
2.11.h. Table comparing features of selected benign and malignant tumors
2.12 Malignant tumors of bone
2.12.a. Historical discussion: Spectrum of premalignant lesions, invasive but non metastatic tumors, low-grade to highly malignant bone tumors
2.12.b. Barriers to tumor expansion; tumor locations in a bone
2.12.c. Osteosarcoma: Definition and pathogenesis
2.12.c.1. Central (syn. medullary, conventional and classic osteosarcoma):
Ultrastructure, staging, grading, genetic biomolecular information. Diagnostic features described for each example
Poorly differentiated
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