Artificial Heart 3 Proceedings of the 3rd International Symposium on Artificial Heart and Assist Devices, February 16–17, 1990, Tokyo, Japan

The International Symposium on Artificial Heart and Assist Devices has been held three times, first in 1985, then in 1987 and 1990. It is my great pleasure to present Artificial Heart 3 (Proceedings of the 3rd International Symposium on Artificial Heart and Assist Devices). The third symposium was held in Tokyo on February 16 and 17, 1990. Our original intention was to invite all the principal investigators from the major artificial heart research laboratories in the world, in the first three symposia. The numbers of investigators in the fields of the artificial heart, ventricular assist systems, and biomaterials, invited for the symposia, totalled 7 in 1985, 8 in 1987, and 13 in 1990. The program of the third symposium consisted of 41 papers; 13 invited lectures, 8 papers contributed upon request, with 2 from the United States, and 20 regular selected papers including 2 from the United States, ana 1 each from Australia, Germany, and South Korea. During the last three years, the state of clinical application of artificial hearts and assist devices has changed. In the case of pneumatically driven blood pumps, we have now stepped into the age of practical use in patients. Accordingly, in this symposium we gave a special emphasis to topics of clinical application, particularly the use of an artificial heart as a bridge to heart transplantation. Sessions on implantable artificial hearts, biomaterials for the artificial heart, and heart transplantation were also included.

I Overview, Artificial Heart Programme.- 1. An overview of the National Heart, Lung, and Blood Institute Artificial Heart Program.- II Biomaterial for Artificial Heart.- 2. Blood compatibility of bioactive polyurethane surfaces.- 3. Evaluation of cytoplasmic free calcium levels in platelets interacting with polymer surfaces.- 4. Blood-compatibility by surface-grafting with polymerizable anticoagulants.- 5. Activation of platelets on well-defined microdomain structures.- 6. Human blood protein and cell interactions with cardiovascular materials.- 7. Retrieval analyses of U-100 Total Artificial Heart blood-contacting surface.- 8. Novel photoreactive surface process technology for fabricated devices.- 9. Effect of polyol chemistry on the in vitro biostability of segmented polyurethanes.- III Pump Design of Artificial Heart.- 10. An electromagnetically driven univalved artificial heart.- 11. Experimental study of nutating centrifugal blood pump in vivo.- 12. Development of artificial heart with left and right ventricles using a linear pulse motor.- 13. Preliminary study — Optimization of spiral vortex blood pump.- 14. Valvo-pump: Axial nonpulsatile blood pump implanted at the heart valve position.- 15. Muscle-powered cardiac assist device (MCAD) for right ventricular support: Current status and future directions.- 16. Pendulum swing artificial heart.- 17. Development of an artificial heart actuator for a compliance chamberless blood pump.- IV Implantable Artificial Heart.- 18. Toward a totally implantable artificial heart: Development status at Cleveland Clinic.- 19. Completely implantable total artificial hearts: Status at the Texas Heart Institute.- 20. Self-regulation of an electrohydraulic total artificial heart.- 21. Motor-driven, computer-controlled implantable cardiac assist device — An optical encoder for feedback control.- 22. The prospective control of a total artificial heart using sympathetic tone and hemodynamic parameters.- 23. Development of a totally implantable electric assist pump system.- 24. The Penn State implantable artificial heart: Current status.- 25. Development of a better fit total artificial heart based on magnetic resonance imaging anatomical study.- 26. Tomasu heart in goat: Analysis of cause of death.- 27. Design of moving-actuator total artificial heart (Korean heart).- 28. Simplified right-left balance for the implanted artificial heart.- V Heart Transplantation.- 29. Cardiac transplantation in the United States of America.- 30. Cardiac transplantation: Australian results.- 31. Heart transplantation — Status in Europe.- 32. Heart and lung preservation using a new solution: UCLA Formula.- 33. Early graft failure after heart transplantation: Circulatory assist versus retransplantation.- 34. Heterotopic heart transplantation for selected high-risk patients.- VI Bridge Use of Artificial Heart.- 35. Bridging to cardiac transplantation with circulatory support devices.- 36. Bridge to transplantation indications for Symbion TAH, Symbion AVAD, and Novacor LVAS.- 37. Univentricular support in a bridge-to-transplant experience.- 38. Use of ventricular assist device (VAD) in patient with end-stage valvular heart disease.- 39. Postcardiotomy patients treated with mechanical circulatory support: Potential candidates for a bridge to transplantation.- 40. A new bridging technique to heart transplantation in patients with ventricular septal perforation and mitral regurgitation after acute myocardial infarction — Feasibility of monoventricularization of bilateral ventricles with LVAD.- Scientific Exhibition.- Key Word Index.