Animal Models of Drug Addiction

Our understanding of addiction and how it is treated has advanced remarkably over the past decades, and much of the progress is related directly to animal research. This is true for both the behavioural aspects of drug use as well as the biological underpinnings of the disorder. In Animal Models of Drug Addiction, experts in the field provide an up-to-date review of complex behavioural paradigms that model different stages of this disorder and explain how each test is used to effectively replicate the progression of drug addiction. This detailed and practical book begins with the most common laboratory measures of addiction in animals, including intracranial self-stimulation (ICSS), drug self-administration, place conditioning, and sensitization. Later chapters describe how these paradigms are used to model the progression of drug addiction, providing insight into the clinical symptomatology of addiction from acquisition of drug use through compulsive drug taking to withdrawal and relapse. Written for the popular Neuromethods series, the contributions offer both methodological detail and a theoretical perspective, appealing to readers familiar with preclinical research on drug addiction as well as those who are newcomers to the field. Cutting-edge and authoritative, Animal Models of Drug Addiction will serve as a basis for future vital research that links the bench to the bedside in the crucial treatment of drug addiction.

Part I: Behavioral Paradigms 1. Intracranial Self-Stimulation Styliani Vlachou and Athina Markou 2. Stimulant Self-Administration Leigh V. Panlilio 3. Opiate Self-Administration Francesco Leri 4. Nicotine Self-Administration Robert E. Sorge and Paul B.S. Clarke 5. Alcohol Self-Administration Friedbert Weiss 6. Place Conditioning Christopher L. Cunningham, Peter A. Groblewski, and Charlene M. Voorhees 7. Sensitization Jessica A. Loweth and Paul Vezina 8. Animal Models of Eating Disorders Stephanie D. Hancock and Mary C. Olmstead Part II: Modeling Stages of Drug Addiction in Animals 9. Acquisition of Drug Self-Administration Marilyn E. Carroll and Richard A. Meisch 10. Escalation of Drug Use Serge H. Ahmed 11. Environmental Modulation of Drug-Taking Aldo Badiani*, Daniele Caprioli, Arianna Testa, Maria Teresa De Luca, and Michele Celentano 12. Craving Jeffrey W. Grimm 13. Habit Formation and Compulsion David Belin, Daina Economidou, Yann Pelloux, and Barry J. Everitt 14. Impulsivity Andrea Bari, Trevor W. Robbins, and Jeffrey W. Dalley 15. Binge Drug-Taking Herbert E. Covington III and Klaus A. Miczek 16. Withdrawal Alasdair M. Barr, Heidi N. Boyda, and Ric M. Procyshyn 17. Relapse Suzanne Erb and Franca Placenza