Part I - Introduction/General
Chapter 1: Aspects of the History and Nomenclature of Amyloid and Amyloidosis
Per Westermark
Chapter 2: Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis
Mario Nuvolone, MD, PhD; Giovanni Palladini, MD, PhD; Giampaolo Merlini, MD
Chapter 3: AA Amyloidosis
Amanda K. Ombrello, MD; Ivona Aksentijevich, MD
Chapter 4: Leukocyte cell-derived chemotaxin 2 Amyloidosis (ALECT2)
Oana Madalina Mereuta, MD PhD; Chris P. Larsen, MD; Ahmet Dogan, MD PhD
Chapter 5: The Hereditary Amyloidoses
Merrill D. Benson, MD
Chapter 6: Dialysis-Associated Amyloidosis
Paweena Susantitaphong, MD; Laura M. Dember, MD; Bertrand L. Jaber, MD, MS
Chapter 7: Localized amyloidoses and amyloidoses associated with aging outside the central nervous system
Per Westermark
Chapter 8: Amyloid Deposition in the Central Nervous System
Fausto J. Rodriguez, Maria M. Picken, John M. Lee
Part II - Non-Amyloid Protein Deposits
Chapter 9: Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis
Guillermo A. Herrera and Elba A. Turbat-Herrera
Chapter 10: Light/Heavy Chain Deposition Disease as a Systemic Disorder
Guillermo A. Herrera and Elba A. Turbat-Herrera
Chapter 11: Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits
Pierre Ronco, Alexandre Karras, and Emmanuelle Plaisier
Chapter 12: Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond
Maria M. Picken and Ahmet Dogan
Part III - Diagnosis
Chapter 13: Diagnosis of Amyloid Using Congo Red
Alexander J. Howie
Chapter 14: Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloidtype-specific Immunohistochemistry: A Review
Reinhold P. Linke, MD, PhD
Chapter 15: Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection
Maria M. Picken and Guillermo A. Herrera
Chapter 16: Fat tissue analysis in the management of patients with systemic amyloidosis
Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg
Chapter 17: Generic diagnosis of amyloid – a summary of current recommendations and the editor’s comments on Chaps. 13-16
Maria M. Picken
Chapter 18: Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloidtype-Specific Immunohistochemistry: A Review
Reinhold P. Linke, MD, PhD
Chapter 19: Amyloid Typing: Experience from a Large Referral Centre
Janet A. Gilbertson, Julian D. Gillmore and Philip N. Hawkins
Chapter 20: Options for amyloid typing in renal pathology – the advantages of frozen section immunofluorescence and a summary of general recommendations regarding immunohistochemistry methods
Maria M. Picken
Chapter 21: Amyloid typing in plastic embedded tissue by immune-gold-silver method
Anne Räisänen-Sokolowski and Tom Tornroth
Chapter 22: The Role of Immuno-electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center
Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Gian Luca Capello, Marco Paulli, and Giampaolo Merlini
Chapter 23: Classification of amyloidosis by mass spectrometry-based proteomics
Ahmet Dogan, MD, PhD
Chapter 24: The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center
Francesca Lavatelli, Francesca Brambilla, Andrea Di Fonzo, Giovanni Ferraro, Giovanni Palladini, Pierluigi Mauri and Giampaolo Merlini
Part IV- Ancillary Studies of Amyloidosis
Chapter 25: Laboratory Support for Diagnosis of Amyloidosis
David L Murray, M.D., Ph.D. and Jerry A. Katzmann, Ph.D.
Chapter 26: Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis
John C. Lee, M.D., Lawreen H. Connors, Ph.D., Carl J. O’Hara, M.D.
Chapter 27: Laboratory Methods for the Diagnosis of Hereditary Amyloidoses
S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr.
Part V- Organ Involvement in Amyloidoses
Chapter 28: Amyloidoses of the Kidney, the Lower Urinary and Genital Tracts (male and female) and the Breast
Maria M. Picken and Ahmet Dogan
Chapter 29: Cardiac Amyloidosis
Carmela D. Tan, M.D. and E. Rene Rodriguez, M.D.
Chapter 30: Amyloidosis of the Gastrointestinal Tract and Liver
Oscar W. Cummings, M.D., Merrill Benson, M.D.
Chapter 31: Peripheral Nerve Amyloidosis
Adam J. Loavenbruck, JaNean K. Engelstad, Christopher J. Klein
Chapter 32: Amyloidosis of the Lymph Nodes and the Spleen
Filiz Sen MD, Ahmet Dogan MD PhD
Chapter 33: Amyloidosis of the lung
Karen L. Grogg MD, Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD
Chapter 34: Cutaneous Amyloidosis
Oana Madalina Mereuta MD PhD, Ahmet Dogan MD PhD
Chapter 35: Iatrogenic pharmaceutical amyloidosis associated with insulin and enfuvirtide administration
Ahmet Dogan MD PhD, Oana Madalina Mereuta MD PhD
Part VI- Clinical Issues and Therapy
Chapter 36: Clinical and pathologic issues in patients with amyloidosis – summary and practical comments regarding diagnosis, therapy and solid organ transplantation
Maria M. Picken and Kevin Barton
Chapter 37: Emerging Therapies for Amyloidosis
Merrill D. Benson
Chapter 38: Modern Therapies in AA Amyloidosis
Amanda K. Ombrello, M.D.
Chapter 39: Medicolegal Issues of Amyloidosis
Timothy Craig Allen, M.D., J.D.
Chapter 40: Amyloidosis from the Patient's Perspective
Muriel Finkel
