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wanner adam (curatore); sandhaus robert a. (curatore) - alpha-1 antitrypsin

Alpha-1 Antitrypsin Role in Health and Disease

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Humana

Pubblicazione: 03/2018
Edizione: Softcover reprint of the original 1st ed. 2016





Trama

This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children and is associated with chronic obstructive lung disease in adults. While it is a rare condition, the mechanisms underlying the clinical manifestations of this deficiency have been largely clarified. Treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases. It concludes with a discussion of rare disorders linked to alpha-1 antitrypsin deficiency and the role of healthcare organizations in the treatment of these diseases. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.





Sommario

Alpha-1- Antitrypsin and the Serpins.- Alpha-1 Antitrypsin: The protein.- Misfolding and Polymerisation of Alpha1-Antitrypsin – Conformational Pathology and Therapeutic Targeting.- Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency.- United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency.- Lung Disease of Alpha-1 Antitrypsin Deficiency.- Alpha-1-Antitrypsin Deficiency: Role in Health and Disease.- Alpha-1 Antitrypsin as a Therapeutic Agents for Conditions not Associated with Alpha-1 Antitrypsin Deficiency.- The Alpha-1 Constellation of Voluntary Health Organizations as a Paradigm for Confronting Other Rare Diseases.




Autore

Adam Wanner, MD
Division of Pulmonary and Critical Care Medicine
Miller School of Medicine
University of Miami
Miami, FL, USA

Robert A. Sandhaus, MD, PhD
Division of Pulmonary, Critical Care, and Sleep Medicine
National Jewish Health
Denver, CO, USA











Altre Informazioni

ISBN:

9783319794846

Condizione: Nuovo
Collana: Respiratory Medicine
Dimensioni: 235 x 155 mm Ø 454 gr
Formato: Brossura
Illustration Notes:X, 173 p. 27 illus., 12 illus. in color.
Pagine Arabe: 173
Pagine Romane: x


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