Albert and Jakobiec's Principles and Practice of Ophthalmology

Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec’s Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4^th edition). 

The 4^th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients' ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees,  this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4^th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. 

Fundamentals of Genetics.-  Molecular Mechanisms of Inherited Disease.-  Genetic Testing.-  Principles of Genetic Counseling.- Immunology – An Overview.-  A Cast of Thousands: The Cells of the Immune System.- T-Lymphocyte Responses.- B-Lymphocyte Responses.- Immune-Mediated Tissue Injury.- Regulation of Immune Responses.- Ocular Bacteriology.- Chlamydial Disease.- The Spirochetes.- Parasitic and Rickettsial Ocular Infections.- Fungal Infections of the Eye.- Ocular Virology.- Ocular Pharmacokinetics.- Anesthetics.- Antibacterials.-  Antivirals.-  Antifungal Agents.- Antiparasitics.- Corticosteroids in Ophthalmic Practice.- Nonsteroidal Antiinflammatory Drugs.- Antihistamines and Mast Cell Stabilizers in Allergic Ocular Disease.-  Tear Film and Blink Dynamics.- Tear Substitutes.- Viscoelastics.- Pharmacologic Agents with Osmotic Effects.- Pharmacologic Treatment of Immune Disorders and Specifically of Immune Ocular Inflammatory Disease.-  Angiogenic Factors and Inhibitors.- Principles of Toxicology of the Eye.- Toxicology of Ophthalmic Agents by Class.- Epidemiology and Clinical Research.- Epidemiology of Age-Related Cataract.- Epidemiology of Primary Open-Angle Glaucoma.-  Epidemiology of Diabetic Retinopathy.- Epidemiology of Age-Related Macular Degeneration.-  Anatomy and Cell Biology of the Cornea, Superficial Limbus, and Conjunctiva.- Corneal Form and Function: Clinical Perspective.-  Ocular Surface Epithelial Stem Cells and Corneal Wound Healing Response to Injury and Infection.-  Corneal Examination, Specular and Confocal Microscopy, UBM, OCT.-  Corneal Dysgeneses, Dystrophies, and Degenerations.-  Keratoconus and Corneal Noninflammatory Ectasias.- Corneal Manifestations of Metabolic Disease.-  Immunologic Disorders of the Conjunctiva, Cornea, and Sclera.- Allergic and Toxic Reactions: The Immune Response.-  48: Lid Inflammations.- Viral Disease of the Cornea and External Eye.-  Bacterial, Chlamydial, and Mycobacterial Infections.-  Fungal Keratitis.-  Acanthamoeba Keratitis.-  Interstitial Keratitis.-  Recurrent Corneal Epithelial Erosion.- Persistent Epithelial Defects.-  Chemical Injuries of the Eye.-  Wetting of the Ocular Surface and Dry-Eye Disorders.- Tumors of the Cornea and Conjunctiva.-  Lamellar Keratoplasty.-  Penetrating Keratoplasty.-  Endothelial Keratoplasty.-  Complications of Corneal Transplantation and Their Management.-  Excimer Laser Phototherapeutic Keratectomy.- Conjunctival Surgery.- Ocular Surface Transplantation.- Amniotic Membrane Surgery.- Keratoprosthesis.- History, Development, and Classification of Refractive Surgical Procedures.- Optical Principles for Refractive Surgery.- Corneal Topography and Wave Front Analysis.-  Diagnosis and Management of Corneal Irregular Astigmatism.-  Biomechanics and Wound Healing in Refractive Surgery.-  Excimer Laser Instrumentation.-  Mechanical and Laser Microkeratomes.-  LASIK Patient Evaluation and Selection.-  Photorefractive Keratectomy for Myopia, Hyperopia, and Astigmatism.-  Decentration in Keratorefractive Procedures.- LASEK and Epi-LASIK.-  LASIK for Myopia, Hyperopia, and Astigmatism.-  Wavefront-Guided Excimer Laser Surgery.-  Intraoperative Complications of LASIK.- Incisional Surgery: Radial and Astigmatic Keratotomy.- Intrastromal Corneal Rings for Myopia, Keratoconus, and Corneal Ectasia.-  Conductive Keratoplasty for the Treatment of Hyperopia and Presbyopia.-  Scleral Procedure for Presbyopia.-  Refractive Surgery with Phakic IOLs.-  Clear Lens Extraction.-  Accommodative and Pseudoaccommodative Intraocular Lenses.-  Future Developments with Conductive Keratoplasty.-  Introduction to Uveitis.-  Immunosuppression.-  Anterior Uveitis.-  Ocular Manifestations of Sarcoidosis.- Intermediate Uveitis.- Infectious Causes of Posterior Uveitis.- Birdshot Chorioretinopathy.-  Vogt–Koyanagi–Harada Disease (Uveomeningitic Syndrome).- Ocular Histoplasmosis.-  Sympathetic Ophthalmia.- Fuchs’ Heterochromic Iridocyclitis.-  Serpiginous Choroiditis.- Intraocular Lymphoproliferations Simulating Uveitis.-  Choroidal Effusions and Detachments.- Biology of the Lens: Lens Transparency as a Function of Embryology, Anatomy, and Physiology.- Lens Proteins and Their Molecular Biology.- Biophysics and Age Changes of the Crystalline Lens.-  Mechanism of Cataract Formation.- Subjective Classification and Objective Quantitation of Human Cataract.-  History of Cataract Surgery.- Historical Development of Modern Intraocular Lens Surgery.-  Preoperative Preparation of Patients for Cataract and Lens Implant Surgery.-  Anesthesia for Cataract Surgery.- Extracapsular Cataract Extraction.- Phacoemulsification – Theory and Practice.-  Fluidics.-  Intraocular Lens Implantation.-  Pediatric Cataract Surgery.-  Combined Procedures.-  Secondary Intraocular Lens Implantation.-  Astigmatism and Cataract Surgery.- Complications of IOL Surgery.- Functional Anatomy of the Neural Retina.-  Visual Acuity, Adaptation, and Color Vision.- Objective Assessment of Retinal Function.- Müller Cells and the Retinal Pigment Epithelium.- Retinal and Choroidal Circulations.- Examination of the Retina: Ophthalmoscopy and Fundus Biomicroscopy.- Principles of Fluorescein Angiography.-  Indocyanine Green Videoangiography.-  Optical Coherence Tomography.- Retinal Arterial Occlusions.-  Retinal Venous Occlusive Disease.- Diagnosis, Management, and Treatment of Nonproliferative Diabetic Retinopathy.- Diabetic Macular Edema.- Proliferative Diabetic Retinopathy.-  Advanced Retinopathy of Prematurity.- Eales’ Disease.-  138: Retinal Arterial Macroaneurysms.-  Coats’ Disease and Retinal Telangiectasia.- Neuroretinitis.-  Familial Exudative Vitreoretinopathy.-  Central Serous Chorioretinopathy.- Genetics of Age-Related Macular Degeneration.-  Age-Related Macular Degeneration: Drusen and Geographic Atrophy.-  Foods and Supplements in the Prevention and Treatment of Age-Related Macular Degeneration.-  Age-Related Macular Degeneration: Choroidal Neovascularization.-  Photodynamic Therapy.-  Anti-VEGF and Other Pharmacologic Treatments for Age-Related Macular Degeneration.-  Surgical Treatments of Neovascular Age-Related Macular Degeneration.-  Acute Idiopathic Maculopathy.-  Idiopathic Polypoidal Choroidal Vasculopathy.-  Angioid Streaks.-  Ocular Histoplasmosis Syndrome.-  Pathologic Myopia.-  Idiopathic Macular Hole.-  Choroidal and Retinal Folds.-  Acute Posterior Multifocal Placoid Pigment Epitheliopathy, Serpiginous Choroiditis, and Relentless Placoid Chorioretinitis.-  Multiple Evanescent White Dot Syndrome.-  Acute Zonal Occult Outer Retinopathy.-  Macular Epiretinal Membranes.-  Acute Macular Neuroretinopathy.- Toxoplasmosis.- Retinal Manifestations of the Acquired Immunodeficiency Syndrome: Diagnosis and Treatment.-  Acute Retinal Necrosis.- Ocular Syphilis.- Subretinal Fibrosis and Uveitis Syndrome.- Diffuse Unilateral Subacute Neuroretinitis.- Frosted Branch Angiitis.-  Retinal Manifestations of the Rheumatic Diseases.-  Retinopathy Associated with Blood Anomalies.- Posterior Segment Sarcoidosis.-  Sickle-Cell Retinopathy.- Traumatic Retinopathy.-  Photic Retinopathy.-  Radiation Retinopathy.-  Retinal Toxicity of Systemic Medications.-  Retinitis Pigmentosa and Allied Diseases.-  Hereditary Cone Dystrophies.- Heredofamilial Macular Degenerations.- Lattice Degeneration, Cystic Retinal Tufts, Asymptomatic Retinal Breaks, and Additional Selected Peripheral Retinal Findings.-  Retinoschisis.-  Retinal Detachment.-  Proliferative Vitre

Dr. Daniel M. Albert is an American ophthalmologist, ophthalmic pathologist, and ocular cancer researcher. He is presently Professor of Ophthalmology at the Casey Eye Institute, Oregon Health and Science University. Dr. Albert earned his medical degree and completed a residency in ophthalmology at the University of Pennsylvania, following which he was a research fellow at the NIH and then an NIH special fellow in ophthalmic pathology at the Armed Forces Institute of Pathology. He assumed his first academic faculty position at Yale University (1969-76), rising to full professor at the Yale Medical School. He then served as Associate Surgeon at the Massachusetts Eye and Infirmary, where he worked with Dr. David G. Cogan and subsequently directed the hospital’s Cogan Eye Pathology Laboratory.  He was Professor of Ophthalmology at Harvard (1976-83) and held that university’s Cogan Professorship in Ophthalmology (1983-92).

In 1992, Dr. Albert was appointed Chair of the Department of Ophthalmology and Visual Sciences and the Frederick A. Davis Professor at the University of Wisconsin School of Medicine and Public Health. He was the founding Director of the University of Wisconsin’s McPherson Eye Research Institute, a position he held for ten years, until he moved to Portland, Oregon in 2016 to assume his current position. During his career Dr. Albert has additionally held visiting appointments across the United States as well as at the University of London and the Institute of Ophthalmology at Moorfields Eye Hospital and has been a guest lecturer in France and Japan.

Dr. Albert was awarded the degree Doctor Honoris Causa from the Universite Louis Pasteur in France in 1984 and also received honorary  degrees from Harvard Medical School (1976) and the Yale School of Medicine (2019). He received the Best Medical Book Award for the 1994 (first) edition of Principles and Practice of Ophthalmology from the Association of  American Publishers. In 2001, he received the University of Pennsylvania School of Medicine’s Distinguished Graduate Award. In 2008 he was recognized with the creation of The Daniel M. Albert Professorship in Visual Sciences established by the University of Wisconsin School of Medicine and Public Health. In 2011 he was named Laureate of the American Academy of Ophthalmology, the society’s highest honor. Dr. Albert has received numerous other awards, including the Albert C. Muse Prize, Association for Research and Vision’s  Friedenwald Award, Humboldt Research Award, American Ophthalmological Society’s Lucien Howe Medal, Pisart Vision Award and the American Association of Ocular Pathologists’ Zimmerman Medal. Dr. Albert served as a director on the American Board of Ophthalmology (1997-2005), Vice-President of ARVO, and President of the American Ophthalmological Society (2005-6).

Joan W. Miller is the David Glendenning Cogan Professor and Chair of the Department of Ophthalmology at Harvard Medical School (HMS), Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital, and Ophthalmologist-in-Chief at Brigham and Women’s Hospital. A graduate of Massachusetts Institute of Technology (MIT), she earned her MD from HMS and completed her ophthalmology residency and vitreoretinal fellowship at Mass Eye and Ear. In 2002, Dr. Miller became the first female physician to achieve the rank of Professor of Ophthalmology at HMS, and in 2003, the first woman to serve as Chair of the Department of Ophthalmology. She is also the first woman appointed as Chief of Ophthalmology at both Mass Eye and Ear and Mass General Hospital.