Advances in Particle Therapy A Multidisciplinary Approach

Hadron therapy is a groundbreaking new method of treating cancer. Boasting greater precision than other therapies, this therapy is now utilised in many clinical settings and the field is growing. More than 50 medical facilities currently perform (or are planned to perform) this treatment, with this number set to double by 2020. This new text covers the most recent advances in hadron therapy, exploring the physics, technology, biology, diagnosis, clinical applications, and economics behind the therapy. Providing essential and up-to-date information on recent developments in the field, this book will be of interest to current and aspiring specialists from a wide range of backgrounds. Features: Multidisciplinary approach: explores the physics, IT (big data), biology, clinical applications from imaging to treatment, clinical trials, and economics associated with hadron therapy Containsthe latest research and developments in this rapidly evolving field, and integrates them into the current global challenges for radiation therapy Edited by recognised leaders in the field, including the co-ordinator of ENLIGHT (the European Network for Light Ion Hadron Therapy), with chapter contributions from international leading experts in the field

Chapter 1: From Röntgen Rays to Carbon Ion Therapy: The Evolution of Modern Radiation Oncology Chapter 2: Radiobiology and Hadron Therapy: What Do We Know and What Do We Need to Know? Chapter 3: Challenges Surrounding RBE for Particle Therapy: Where Do We Go from Here? Chapter 4: Advances in Beam Delivery Techniques and Accelerators in Particle Therapy Chapter 5: Requirements for Setting up a Particle Therapy Center Chapter 6: Imaging and Particle Therapy: Current Status and Future Perspectives Chapter 7: Why Particle Therapy rather than Photon Therapy or How to Integrate the Decision into Multimodal Management. Chapter 8: Role of Multidisciplinary Collaborative Network for Advancing Cancer Therapy Chapter 9: Long-term Outcomes and Prognostic Factors in Patients with Indications for Particle Therapy in Sarcomas Chapter 10: Proton therapy for Pediatric Patients Chapter 11: NTCP Reduction in Advanced Head and Neck Cancer Patients Using Proton Therapy Chapter 12: The Model-based Approach to Select Patients for Proton Therapy and to Validate its Added Value Chapter 13: Overview of Carbon-Ion Radiotherapy in Japan Chapter 14: Particle Therapy Clinical Trials: Perspectives from Europe, Japan and USA Chapter 15: Role of Particle Therapy in Future Radiotherapy practice Chapter 16: Health Economics: Cost, Cost-Effectiveness and Budget Impact of Particle Therapy Chapter 17: Big Data-based Decision Support Systems for Hadrontherapy Chapter 18: CERN Collaborations in Hadron Therapy and Future Accelerators Chapter 19: Addressing Global Challenges for Radiation Therapy: From “C” to shining “C” (Cobalt to Carbon) and the “Radiation Rotary”.

Manjit Dosanjh is the co-ordinator of the Technology Transfer Network and Biomedical Applications in the Education and Technology Transfer Division at CERNand a Health Consultant forthe Forum for Health. She is also the co-ordinator of ENLIGHT (the European Network for Light Ion Hadron Therapy). Jacques Bernier is the Medical Director of the Oncology Department of the Clinique de Genolier and the Integrated Center for Radiation Oncology of Eaux-Vives in Geneva. He is also Course Director at the European School of Oncology.