Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index.
This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations.
Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.
1. Introduction to cancer cell biology 2. Current practice in cancer pharmacotherapy 3. Current practices in oncology drug delivery 4. Emerging need of advanced drug delivery systems in cancer 5. Target drug delivery in cancer 6. Material and strategies used in oncology drug delivery 7. Hydrogel based drug delivery systems for cancer therapy 8. Recent advances in drug formulation development for targeting lung cancer 9. Advanced drug delivery systems in lung cancer 10. Advanced drug delivery systems in breast cancer 11. Advance drug delivery systems in the treatment of ovarian cancer 12. Advanced drug delivery systems in blood cancer 13. Advanced drug delivery systems in kidney cancer 14. Advance drug delivery systems in glioblastoma 15. Advanced drug delivery systems in prostate cancer 16. Nanomedicine-based doxorubicin delivery for skin cancer with theranostic potential 17. Advanced drug delivery systems in liver cancer 18. Advanced drug delivery systems in hepatocellular carcinoma 19. Advanced drug delivery systems in oral cancer 20. Advance drug delivery system in pancreatic cancer 21. Advanced drug delivery system in colorectal cancer 22. Current strategies in targeted anticancer drug delivery systems to brain 23. Neuroblastoma: Current advancements and future therapeutics 24. Nanoparticulate systems and their translation potential for breast cancer therapeutics 25. Advancement on nanoparticle-based drug delivery systems for cancer therapy 26. Advances in polymeric nanoparticles for drug delivery systems in cancer: Production and characterization 27. Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics 28. Advancements on microparticles-based drug delivery systems for cancer therapy 29. Microparticles for cancer therapy 30. Biosynthetic exosome nanoparticles isolation, characterization, and their diagnostic and therapeutic applications 31. Advances in delivery of nanomedicines and theranostics for targeting breast cancer 32. Bioresponsive nano-theranostics approaches for cancer targeting 33. Two-dimensional materials-based nanoplatforms for lung cancer management: Synthesis, properties, and targeted therapy 34. Cell and gene therapies - Emerging technologies and drug delivery systems for treating brain cancer 35. Targeting siRNAs in cancer drug delivery 36. Targeting micro-ribonucleic acid (miRNA) in cancer using advanced drug delivery systems 37. Organic nanocarriers for targeted delivery of anticancer agents 38. Targeting cancer using phytoconstituents-based drug delivery 39. Clinical trials in drug delivery for the treatment of cancer 40. Future prospects and challenges in cancer drug delivery