Abeta Peptide and Alzheimer's Disease Celebrating a Century of Research

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). Abeta Peptide and Alzheimer’s Disease is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD.

Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinsons and Huntingtons. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.

A Brief Introduction to the History of the ß-Amyloid Protein (Aß) of Alzheimer’s Disease.- The Aßcentric Pathway of Alzheimer’s Disease.- The Function of the Amyloid Precursor Protein Family.- The involvement of Aß in the neuroinflammatory response.- Amyloid ß-Peptide(1-42), Oxidative Stress, and Alzheimer’s Disease.- Amyloid Toxicity, Synaptic Dysfunction and the Biochemistry of Neurodegeneration in Alzheimer’s Disease.- Aß Variants and Their Impact on Amyloid Formation and Alzheimer’s Disease Progression.- Copper Coordination by ß-Amyloid and the Neuropathology of Alzheimer’s Disease.- Cholesterol and Alzheimer’s Disease.- Amyloid ß peptide and central cholinergic neurons: involvement in normal brain function and Alzheimer’s disease pathology.- Physiological and Neurotoxic Properties of Aß Peptides.- Impact of ß-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models.- Glial Cells and Aß Peptides in Alzheimer’s Disease Pathogenesis.- The Role of Presenilins in Abeta-Induced Cell Death in Alzheimer’s Disease.- Immunotherapeutic approaches to Alzheimer’s disease.- Mouse Models of Alzheimer’s Disease.