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alfinito eleonora; pousset jeremy; reggiani lino - proteotronics

Proteotronics Development of Protein-Based Electronics

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Dettagli

Genere:Libro
Lingua: Inglese
Pubblicazione: 09/2015
Edizione: 1° edizione





Note Editore

Protein-mediated charge transport is of relevant importance in the design of protein-based electronics and in attaining an adequate level of understanding of protein functioning. This book reviews a variety of experiments devoted to the investigation of charge transport in proteins and presents a unified theoretical model to interpret macroscopic results in terms of the amino acids backbone-structure of the single protein. It aims to serve a broad audience of researchers involved in the field of electrical characterization of biological materials and in the development of new molecular devices based on proteins and also as a reference platform that surveys existing data and presents the basis for future development of a new branch of nano-electronics, which by mixing proteomics, that is, the large-scale study of proteins, particularly their structures and functions, and electronics is introduced here as proteotronics.




Sommario

Preface Introduction General on Proteins Structural Properties Structure Levels Protein Folding Experimental Techniques to Investigate Structure and Functions of Proteins Classification of Proteins Sensing Proteins Type-One Opsins G-Protein Coupled Receptors GPCR Activation Models Structure and Sensing Action Electrical Characterization Main Properties of Investigated Proteins Electrical Properties: Experiments General Electrochemical Impedance Spectroscopy Model Lipid Bilayer Immobilization of GPCRs Experimental Results Carbon Nanotube Field-Effect-Transistor Metal-Protein-Metal Structure: Thin Film Technique Metal-Protein-Metal Structure: Nanolayer Technique Atomic Force Microscopy Technique Electrical Properties: Theory Theoretical Model Impedance Random Network Electrical Properties of a Single Protein Network Properties of the Protein Under Test Calculation of a Single-Protein Molecular Volume Conformational Process: General Conformation Process: Coordinate Model Conformation Process: Length Model Topological Investigation Resistance and Impedance Spectrum Random Fluctuations in the Impedance Network Dynamic Fluctuations of the Impedance Network: Oscillator Models Classical Harmonic Oscillator Link oscillation model Node Oscillation Model Results on Average Quantities Variance of Impedance Fluctuations Quantum Harmonic Oscillator Current-Voltage Characteristics Bacteriorhodopsin as Testing Prototype Modeling Topological Properties Current–Voltage Characteristics Scaling and Universality of High-Field Conductance in Bacteriorhodopsin Monolayers Global Quantities Generalized Gumbel Distributions Discussion Conclusion Survey of Other Proteins Proteorhodopsin Modeling Topological Properties Experiments A Comparative Analysis of Proteorhodopsin and Bacteriorhodopsin Electrical Properties Protein Resistance Small-signal electrical properties Current–voltage characteristics Conclusion Bovine Rhodopsin Modeling Engineering of Bovine Rhodopsin Spatial Structure Small-Signal Electrical Properties Current–Voltage Characteristics Conclusion Rat OR-I7 Modeling Topological Properties Small-Signal Electrical Properties Current–Voltage Characteristics Conclusion Human OR 17-40 Modeling Topological Properties Protein Resistance Small-Signal Electrical Properties Conclusion OR 7D4 Modeling Topological Properties Protein Resistance Small-Signal Electrical Properties Conclusion Human OR 2AG1 Modeling Topological Properties Protein Resistance Small-Signal Electrical Properties Conclusion Canine Cf OR 5269 Modeling Topological Properties Protein Resistance Small-Signal Electrical Properties Conclusion Azurin Modeling Topological Properties Protein Resistance Current–Voltage Characteristics Conclusion AChE Modeling Topological Properties Small-Signal Electrical Properties Conclusion Conclusion and Perspectives Appendix: Computational Details Calculation of Small-Signal Impedance Spectrum Analysis of the Protein Equivalent Circuit Obtained from Calculations of Bovinerhodopsin and AChE Calculations of Intrinsic Fluctuations of the Single-Protein Impedance Due to the Presence of Defects Calculations of Intrinsic Fluctuations of the Single-Protein Impedance due to Thermal Fluctuations Calculations of Static High-Field Current–Voltage Characteristics Inclusion of the Fowler–Nordheim Tunneling Mechanism List of acronyms Bibliography Index




Autore

Eleonora Alfinito is a researcher in condensed matter physics at the University of Salento, Lecce, Italy. Her research activity is founded on quantum field theory, physics of matter, and mathematical physics. At present, her main interests concern with the electrical properties of biological matter, proteins in particular, and the statistical characterization of electrical fluctuations. Jeremy Pousset is a researcher at the Institute for Microelectronics and Microsystems of the National Research Council, Lecce, Italy. His research activity has been devoted to the problem of terahertz plasma waves in nano-devices and the development of Monte Carlo codes and the investigation of electron transport modelling of biological matter. Currently, he is working on the electrical characterization of organic materials. Lino Reggiani is full professor in physics of matter at the University of Salento, where he is carrying out a research activity finalized to the study of electrical properties and fluctuations to characterize materials and devices to be used in nano-electronics and in the development of sensors. He has authored and co-authored over 500 scientific publications in specialized international magazines.










Altre Informazioni

ISBN:

9789814613637

Condizione: Nuovo
Dimensioni: 9 x 6 in Ø 1.19 lb
Formato: Copertina rigida
Illustration Notes:140 b/w images and 30 color images
Pagine Arabe: 280


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