Taxol Science and Applications

This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.

IntroductionDiscovery and Development of TAXOL®, M. Suffness and M.E. WallYew and Us: A Brief History of the Yew Tree. H.R. Hartzell, Jr.Supply of TAXOL®Taxus for TAXOL® and Taxoids, E.M. Croom, Jr.Potential of Plant Cell Culture for Taxane Production, D.M. Gibson, R.E.B. Ketchum, T.J. Hirasuna, and M.L. ShulerSemisynthesis of TAXOL® and Taxotere, R.A. Holton, R.J. Biediger, and P. Douglas BoatmanToward the Total Synthesis of TAXOL® and Its Analogues, P.A. Wender, M.G. Natchus, and A.J. ShukerBiology of TAXOL®Biosynthesis of TAXOL®, H.G. Floss and U. MocekPreclinical Antitumor Activity of Taxanes, W.C. RoseBiopharmaceutics of Paclitaxel (TAXOL®): Formulation, Activity, and Pharmacokinetics, R.M. StraubingerThe Use of TAXOL® in Cell Biology, R.B. ValleeChemistry of TAXOL®Detection and Isolation, K.M. SnaderNatural Taxoids: Structure and Chemistry, D.G.I. KingstonThe Medicinal Chemistry of TAXOL® , G.I. Georg, T.C. Boge, Z.S. Cheruvallath, J.S. Clowers, G.C.B. Harriman, M. Hepperie, and H. ParkClinical StudiesTAXOL® : Clinical Results and Current Issues in Development, S.G. Arbuck and B.A. BlaylockIndex

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