Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the<BR>biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for<BR>therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of<BR>these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of<BR>hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be<BR>illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells andendothelial cells during development and in the adult. Evidence suggests that<BR>endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with h
Part I Hematopoietic Progenitors & Stem Cells; 1: Donald Metcalf: Nature of Hematopoietic Development as Deducible from Clonal Cultures; 2: Irving L. Weissman and Koichi Akashi: Stem Cells and Hematolymphoid Development; 3: Gerry Spangrude, William B. Slayton, and Suzanne Pohlmann: Stem Cell Populations and Purification; 4: Ihor Lemischka: Subtractive Approach to Cloning Genes that Regulate Hematopoiesis; 5: Tariq Enver and Gillian May: Lineage Commitment and Self-Renewal of Blood Stem Cells; 6: Makio Ogawa and Anne G. Livingston: Blast Cell Colony Assays; 7: Connie Eaves, Eibhlin Conneally, Donna Hogge, and Heather Sutherland: Quantitative Studies of Normal and Leukemic Stem Cells: Definition and Regulation; 8: John E. Dick, Jean CY Wang, Craig Dorrell, Caryn Y Ito, Takeshi Inamitsu, Guillermo Guenechea, and Olga I. Gan: Normal and Leukemic Stem Cells Assayed in Immune-Deficient; 9: Catherine Verifaille: Ex Vivo Expansion of Hematopoietic Stem Cells; 10: David Bodine: Hematopoietic Stem Cell Gene Therapy: Progress and Prospects; Part II Early Embryology and Ontogeny; 11: Shuo Lin: Zebrafish Hematopoietic Development; 12: Todd Evans: Blood Formation During Xenopus Embryogenesis; 13: Margaret Baron: Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis; 14: Shin-Ichi Nishikawa, Satomi Nishikawa, Stuart Fraser, Tesuhiro Fujimoto, Hisahiro Yoshida, Masanori Hirashima, and Minetaro Ogawa: Developmental Relationships of Hematopoietic Stem Cells and Endothelial Cells; 15: Mervin Yoder and James Palis: Ventral (Yolk Sac) Hematopoiesis in the Mouse; 16: James B. Turpen: Dorsal Hematopoiesis in Fish and Amphibians; 17: Fran?oise Dieterlen-Lievre, Luc Pardanaud, Aianna Caprioli, and Thierry Jaffredo: Non-Yolk Sac Hematopoietic Stem Cells: The Avian Paradigm; 18: Elaine Dzierzak and Robert Oostendorp: Hematopoietic Stem Cell Development in Mammals; 19: Ana Cumano, I. Godin, S. Delassus, F. Dieterlen-Lievre, and V. Barreto: Changes in Lymphoid Progenitor Populations During Mammalian Development; 20: Michael Wyles and Gabrielle Proetzel: Use of Embyronic Stem Cell In Vitro Differentiation in a Serum-Free Environment for Analysis of Mesoderm Formation and Hematopoietic Development; 21: Bernard Mathey-Prevot: Drosophila Hematopoiesis; Part III Important Factors in Hematopoiesis; 22: Hal Broxmeyer: Regulation of Myelopoiesis as Assessed by Gene Deletion and Gene Transduction; 23: Atsushi Miyajima, Takahiko Hara, and Koh Nakayama: Hematopoietic Signal Transduction; 24: Brian Druker and Jennifer Rhodes: Jak-STAT Signal Transduction; 25: Gregg Semenza: Regulation of Erythropoietin Production: Molecular Mechanisms of Oxygen Homeostasis; 26: John Yu: Involvement of Activins and TGFBs in Hematopoiesis; 27: Ronald Hoffman and David J. Van Den Berg: Wnts and Hematopoiesis; 28: Malcolm Moore, Wei Han, Qian Ye: Notch Signaling During Development; 29: Thalia Papayannopoulou: VLA/B1 Integrins in Hematopoiesis; 30: Craig Gerard: Chemokines; 31: Janice Gabrilove: Fetal Growth Factor and Hematopoiesis; 32: Stuart Orkin: Transcriptional Control During Erythroid and Megakaryocytic Development; 33: Thomas Graf and Achim Leutz: Transcription Factors that Induce Commitment of Multipotent Hematopoietic Progenitors: Lessons from the MEP System; 34: Claus Nerlov, Daniel G. Tenen, and Thomas Graf: Regulatory Interactions between Transcription Factors and Their Role in Hematopoietic Lineage Determination; 35: Hartmut Beug, Anton Bauer, Jacques Samarut, and Olivier Gandrillon: Nuclear Receptors in Hematopoietic Development: Cooperation with Growth Factor Receptors in Regulation of Proliferation and Differentiation; 36: Celeste Simon, Richard Dahl, and Renee D. Hackenmiller: Ets Transcription Factor Mutations and Hematopoiesis; 37: H.Jeffrey Lawrence, Guy Sauvageau, Corey Largman, and R. Keith Humphries: Homeobox Genes and the Regulation of Hematopoiesis; Part IV Myeloid Biology; 38: Daniel Tenen: Myeloid Transcription Factors and Development; 39: Jerome Groopman, Daniel J. Price, and Hava Avraham: Megakaryocyte Signaling; 40: Stephen D. Nimer: Transcription Factors Active in Megakaryocytic Development; 41: Ken Kaushansky and Jonathan G. Drachman: The Role of Myeloproliferative Leukemia in Megakaryopoiesis; 42: Stephen Galli and Chris S. Lantz: Mast Cell and Basophil Development; 43: Stephen Emerson, Russell S. Taichman, and Scott Adams: The Role of Osteoblasts in Hematopoietic Stem Cell Biology; Part V Lymphoid Biology; 44: Katia Georgopolous, Joseph Koipally, Clair M. Kelley, and Marta Cortes: Role of Ikaros Proteins in Lymphocyte Development and Function; 45: Jeffrey Leiden and Chay Kuo: Transcriptional Regulation of T Cell Development and Activation; 46: Steven J. Burakoff and Jyoti Sen: Signal Tranduction in Thymic Development; 47: Laurie Glimscher, Ann M. Ranger, and I- Cheng Ho: Lineage Commitment of CD4 T Helper Lymphocytes; 48: John G. Gribben and Joachim Schultze: B-Cell Development and Maturation; 49: Frederick Alt: Development of the Recombinase System; 50: Gary Litman, Ann L. Miracle, Noel A. Hawke, and Michele K. Anderson: The Phylogenetic Development of the Cells that Express and Mechanisms that Diversify Immunoglobulins and T-cell Antigen Receptors; Part VII Genetics of Blood Formation During Development; 51: Leonard I. Zon: Zebrafish Hematopoietic Mutants; 52: Luanne Peters and Jane E. Barker: Spontaneous and Targeted Mutations in Erythrocyte Membrane Skeleton Genes: Mouse Models of Hereditary Spherocytosis; 53: Colin Sieff: Human Bone Marro Failure Syndromes; 54: Robert H. Broyles: Globin Switching and Developmental Changes in Erythropoietic Sites and Red Blood Cell Populations of Non-Mammalian Vertebrates; 55: George Stammatoyannopoulos: Globin Switching; 56: David Williams: Dominant White Spotting and Steel Mutants in Hematopoiesis; 57: Chris Amemiya and Tohru Ikuta: Genomics and Developmental Biology; 58: A. Thomas Look: Acute Leukemia: A Disease of Disordered Cell Fate Determination; Part VII Stroma; 59: Pierre Charbord: The Microenvironmental Cell Populations Essential for the Support of Hematopoietic Stem Cells; 60: Pierre Charbord: The Mediators Involved in the Control of Hematopoiesis by the Microenvironment; 61: Paul J. Simmons, Andrew CW Zannettino, and Stan Gronthos: Development of Stromal Cells; 62: Christa Muller-Sieburg: Mouse Genetics for the Analysis of Stem Cell Behavior; Part VIII Vasculogenesis; 63: Alan Bernstein, Mira C. Puri, and William L. Stanford: Receptor Tyrosine Kinases in Endothelial and Hematopoietic Cell Development; 64: K. Alitalo, Yuji Gunji, Ritta Alitalo, and Anne Eichmann: Vascular Endothelial Growth Factor Receptors in Vascular Development and Hematopoiesis; 65: Shahin Rafii: Regulation of Hematopoiesis by Bone Marrow Microvascular Endothelium; 66: Bjorn Olson, L. Karttunen, Ute Felbor, and M. Vikkula: Vascular Matrix and Disorders; 67: Judah Folkman: Vasculogenesis; 68: G. D. Yancopoulos, Samuel Davis, Jocelyn Holash, Chitra Suri, Peter C. Maisonpierre, and Stanley J. Wiegand: The Angiopoietins and How They Act Coordinately with Vascular Endothelial Growth Factors During Normal and Pathologic Angiogenesis; INDEX
Dimensioni: 279x216 mm.
Illustration Notes:24pp colour plates, numerous line figures and black and white photographs
Pagine Arabe: 856