Handbook of Small Animal Imaging Preclinical Imaging, Therapy, and Applications

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.

INTRODUCTION TO SMALL ANIMAL IMAGING, THERAPY, AND APPLICATIONSDefining Small Animal Imaging, Therapy, and ApplicationsNancy L. Ford, George K. Loudos, Dimitrios N. Karnabatidis, and George C. KagadisEthics and Regulations for Research with AnimalsWilliam R. HendeeSmall Animal Handling, Care, and AnesthesiaTamara GodbeyPreclinical ModelsIrene Cuadrado, Jesús Egido, Jose Luis Zamorano, and Carlos Zaragoza SMALL ANIMAL IMAGING: IONIZING RADIATIONMicrocomputed TomographyNancy L. FordDigital Subtracted Angiography of Small AnimalsStavros Spiliopoulos, George C. Kagadis, Dimitrios N. Karnabatidis, G. Allan Johnson, and Cristian BadeaSingle-Photon Emission Computed TomographyMatthew A. LewisPositron Emission TomographyVesna Sossi and Matthew Walker SMALL ANIMAL IMAGING: NONIONIZING RADIATIONMR ImagingDmitri ArtemovOptical ImagingMatthew A. Lewis HYBRID IMAGINGOptical-CT ImagingXueli Chen, Dongmei Chen, FengLin Liu, Wenxiang Cong, Ge Wang, and Jimin LiangPET/CTMohammad Reza Ay and Nafiseh GhazanfariIntroduction to Combining MRI with PETVolkmar Schulz, Jakob Wehner, and Yannick BerkerExotic Imaging ApproachesMaria Koutsoupidou and Irene S. Karanasiou IMAGING AGENTSX-Ray, MRI, and Ultrasound Agents: Basic PrinciplesMichael F. Tweedle, Krishan Kumar, and Michael V. KnoppRadiochemistry for Preclinical Imaging StudiesSven Macholl and Matthias GlaserMolecular Targets and Optical ProbesEleni K. Efthimiadou and George Kordas THERAPEUTIC RESEARCH PLATFORMSDeveloping Technologies for Small Animal RadiotherapyFrank Verhaegen, James Stewart, and David JaffrayDosimetry of Ionizing Radiation in Small Animal ImagingMichael G. StabinTreatment Planning for Small AnimalsFrank VerhaegenRadiolabeled Agents for Molecular Imaging and/or TherapyDimitrios Psimadas and Eirini A. Fragogeorgi IMAGE QUANTIFICATIONQuantification in Nuclear Preclinical ImagingIstvan SzandaPerformance Assessment of Small Animal Imaging Systems and Common StandardsNancy L. FordMonte Carlo Simulations in Imaging and TherapyPanagiotis Papadimitroulas, George C. Kagadis, and George K. Loudos APPLICATIONS: INCLUDES BOTH IMAGING AND THERAPYSmall Animal Imaging and Therapy: How They Affect Patient CareLawrence W. DobruckiApplications for Drug DevelopmentJeßica Kalra, Donald T. Yapp, Murray Webb, and Marcel B. BallyImaging of Intracellular TargetsVeerle KersemansImaging of Cell Trafficking and Cell Tissue HomingVeerle KersemansImaging of Cardiovascular DiseaseAleksandra Kalinowska and Lawrence W. DobruckiImaging AngiogenesisLawrence W. DobruckiImaging of Hypoxia, Apoptosis, and InflammationStavros Spiliopoulos and Athanasios DiamantopoulosVessel Wall ImagingStavros Spiliopoulos

George C. Kagadis, PhD, FAAPM, is an associate professor of medical physics and medical informatics at the University of Patras. He also holds an adjunct assistant professor appointment at the University of Texas MD Anderson Cancer Center. He is a Greek State Scholarship Foundation grantee, a Fulbright research scholar, and a fellow of the American Association of Physicists in Medicine (AAPM). He has authored about 80 journal papers and presented at more than 20 conferences. He received his PhD in medical physics from the University of Patras. His current research interests focus on medical image processing and analysis, studies in molecular imaging, IHE, and CAD applications. Nancy L. Ford, PhD, is an assistant professor in the Department of Oral, Biological and Medical Sciences and the director of the Centre for High-Throughput Phenogenomics at the University of British Columbia. She is a full member of the AAPM and an associate editor of Medical Physics. She publishes in journals on medical physics, radiology, and dental science. She received her PhD in medical biophysics from the University of Western Ontario. Her research focuses on preclinical micro-computed tomography imaging and image-based analysis, primarily studying models of respiratory diseases, along with CBCT and MSCT for medical and dental applications. Dimitrios N. Karnabatidis, PhD, EBIR, is an associate professor of interventional radiology at the University of Patras. He is a fellow of the Cardiovascular and Interventional Radiological Society of Europe and a member of the Hellenic Radiology Society, the Hellenic Society of Interventional Radiology, and the Western Greece Radiology Society. He has been involved as a participant/principal investigator in several national/international research projects and has published 122 articles in peer-reviewed journals. He received his PhD from the School of Medicine, University of Patras. His research interests include angiogenesis in malignant and benign diseases, the augmentation of arteriogenesis in critical limb ischemia, endothelial hyperplasia inhibition after endovascular procedures, and ureteral obstructive diseases. George K. Loudos, PhD, is an assistant professor in the Department of Biomedical Engineering at the Technological Educational Institute of Athens. He has published 89 articles in international journals and more than 200 papers in conference proceedings. He received his PhD in biomedical engineering from the National Technical University of Athens. His research interests focus on molecular imaging using nuclear medicine techniques and medical instrumentation. He strongly supports interdisciplinary cooperation and education in the field of nanomedicine and molecular imaging.