Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques

Now updated to cover all the areas of interest in the field of capillary electrophoresis (CE), this third edition brings together cutting-edge researchto demonstrate the utility of CE across a broad spectrum of disciplines including forensic science, medical diagnostics, and pharmaceutical science.

Although capillary electrophoresis (CE) technology has evolved quickly from the research laboratory into practical application in numerous fields, many scientists still debate its merits. While the body of international CE literature continues to expand dramatically, experts still question whether it has provided the speed, resolving power, peak capacity, sensitivity, robustness, and cost-reduction promised by its pioneers. Responding to these criticisms, this third edition brings together cutting-edge researchers to demonstrate the utility of CE across a broad spectrum of disciplines including— Forensic science Medical diagnostics Pharmaceutical science Genetic analysis Biotechnology Fluid mechanics Environmental science Biomedical research Nanotechnology Proteomics Detailed Analysis of New Methodologies and Applications Eagerly awaited by researchers and technicians who transformed the first two editions into bestsellers, this latest volume once again delivers. Emphasizing microseparations and microfluidics, the Handbook of Capillary and Microchip Electrophoresis, Third Edition features new chapters describing the use of microchip electrophoresis and associated microtechniques, with a focus on the extraordinary breadth of work undertaken to expand CE methodologies in recent years. Aided by contributions from leading international experts, this text remains a seminal reference for numerous chemistry, biology, and engineering fields.

Part I Fundamentals and Methodologies Introduction to Capillary Electrophoresis, J.P. Landers Protein Analysis by Capillary Electrophoresis, J.M. Hempe Micellar Electrokinetic Chromatography, S. Terabe Capillary Electrophoresis for Pharmaceutical Analysis, E. McEvoy, A. Marsh, K. Altria, S. Donegan, and Joe Power Principles and Practice of Capillary Electrochromatography, M.T. Koesdjojo, C.F. Gonzalez, and V.T. Remcho Capillary Electrophoresis of Nucleic Acids, E. Szántai and A. Guttman Analysis of Carbohydrates by Capillary Electrophoresis, J. Khandurina The Coupling of Capillary Electrophoresis and Mass Spectrometry in Proteomics, H.J. Issaq and T.D. Veenstra Light-Based Detection Methods for Capillary Electrophoresis, C. Scanlan, T. Lapainis, and J.V. Sweedler Microfluidic Devices for Electrophoretic Separations: Fabrication and Use, L. A. Legendre, J. P. Ferrance, and J.P. Landers Part IIA Capillary-Based Systems: Core Methods and Technologies Kinetic Capillary Electrophoresis, M.V. Berezovski and S.N. Krylov DNA Sequencing and Genotyping by Free-Solution Conjugate Electrophoresis, J.A. Coyne, J.S. Lin, and A. E. Barron Online Sample Preconcentration for Capillary Electrophoresis, D.S. Burgi and B.C. Giordano Capillary Electrophoresis for the Analysis of Single Cells: Sampling, Detection, and Applications, I. G. Arcibal, M.F. Santillo, and A.G. Ewing Ultrafast Electrophoretic Separations, M.G. Roper, C. Guillo, and B. J. Venton DNA Sequencing by Capillary Electrophoresis, D.L. Yang, R. Sauvageot, and S.L. Pentoney, Jr. Dynamic Computer Simulation Software for Capillary Electrophoresis, M.C. Breadmore and W. Thormann Heat Production and Dissipation in Capillary Electrophoresis, C.J. Evenhuis, R.M. Guijt, M. Macka, P.J. Marriott, and P.R. Haddad Isoelectric Focusing in Capillary Systems, J.W. T. Huang, and J. Pawliszyn Part IIB Capillary-Based Systems: Specialized Methods and Technologies Subcellular Analysis by Capillary Electrophoresis, B.G. Poe and E.A. Arriaga Chemical Cytometry: Capillary Electrophoresis Analysis at the Level of the Single Cell, C.Whitmore, K. Sobhani, R. Bonn, D. Mao, E. Turner, J. Kraly, D. Michels, M. Palcic, O. Hindsgaul, and N.J. Dovichi Glycoprotein Analysis by Capillary Electrophoresis, M. Girard, I. Lacunza, J.C. Diez-Masa, and M. de Frutos Capillary Electrophoresis of Post-Translationally Modified Proteins and Peptides, B. Sarg and H.H. Lindner Extreme Resolution in Capillary Electrophoresis: UHVCE, FCCE, and SCCE, W. H. Henley and J.W. Jorgenson Separation of DNA for Forensic Applications Using Capillary Electrophoresis, L.I. Moreno and B. McCord Clinical Application of CE, Z.K. Shihabi Solid-Phase Microextraction and Solid-Phase Extraction with Capillary Electrophoresis and Related Techniques, S. G. Weber CE-SELEX: Isolating Aptamers Using Capillary Electrophoresis, R.K. Mosing and M.T. Bowser Microfluidic Technology as a Platform to Investigate the Microcirculation, D.M. Spence Capillary Electrophoresis Applications for Food Analysis, B.Vallejo-Cordoba and M. G. Vargas Martínez Separation Strategies for Environmental Analysis, F. G. Tonin and M.F.M. Tavares Part IIIA Microchip-Based: Core Methods and Technologies Cell Manipulation at the Micron Scale, T. M. Keenan and D. J. Beebe Multidimensional Microfluidic Systems for Protein and Peptide Separations, D.L. DeVoe and C.S. Lee Microchip Immunoassays, K. Sato and T. Kitamori Solvent Extraction on Chips, M. Tokeshi and T. Kitamori Electrophoretic Microdevices for Clinical Diagnostics, J.P. Ferrance Advances in Microfluidics: Development of a Forensic Integrated DNA Microchip (IDChip), K.M. Horsman and J.P. Landers Taylor Dispersion in Sample Preconcentration Methods, R. Bharadwaj, D.E. Huber, T. Khurana, and J.G. Santiago The Mechanical Behavior of Films and Interfaces in Microfluidic Devices: Implications for Performance and Reliability, M.R. Begley and J. Monahan Practical Fluid Control Strategies for Microfluidic Devices, C.J. Easley and J.P. Landers Low-Cost Technologies for Microfluidic Applications, W.K. Tomazelli Coltro and E. Carrilho Microfluidic Reactors for Small Molecule and Nanomaterial Synthesis, A.J. deMello, C.J. Cullen, R. Fortt, and R.C.R. Wootton Part IIIB Microchip-Based: Specialized Methods and Technologies Sample Processing with Integrated Microfluidic Systems, J.M. Bienvenue and J.P. Landers Cell and Particle Separation and Manipulation Using Acoustic Standing Waves in Microfluidic Systems, T. Laurell and J.Nilsson Optical Detection Systems for Microchips, J.M. Karlinsey and J.P. Landers Microfabricated Electrophoresis Devices for High-Throughput Genetic Analysis: Milestones and Challenges, C.A. Emrich and R.A. Mathies Macroporous Monoliths for Chromatographic Separations in Microchannels, F. Svec and T.B. Stachowiak Microdialysis and Microchip Systems, B.A. Fogarty, P. Nandi, and S.M. Lunte Microfluidic Sample Preparation for Proteomics Analysis Using MALDI-MS, S. Ekström, J. Nilsson, G. Marko-Varga, and T. Laurell Implementing Sample Preconcentration in Microfluidic Devices, P. M. van Midwoud and E. Verpoorte Using Phase-Changing Sacrificial Materials to Fabricate Microdevices for Chemical Analysis, H V. Fuentes and A.T. Woolley Materials and Modification Strategies for Electrophoresis Microchips, C. S. Henry and B.M. Dressen Microfluidic Devices with Mass Spectrometry Detection, I. M. Lazar Nanoscale Self-Assembly of Stationary Phases for Capillary Electrophoresis of DNA, K.D. Dorfman and J.L. Viovy Nanoscale DNA Analysis, L. Mahmoudian, M.R. Mohamadi, N. Kaji, M. Tokeshi, and Y. Baba Index

James P. Landers