This book describes how the general engineering design science theory can be applied when designing a technical system where biological species or components are integrated. These biotechnology-related mechatronic systems are combined designs between traditional electronic and mechanical sub-systems and biological systems. The book demonstrates how biotechnology and bioengineering design can utilize and benefit from commonly used design tools in mechanical and electric engineering. These tools should then contribute to shorter development times and a reduction of the need for prototype testing and verification. The reader will be able to apply the insights in the book to product development work in e.g. small-scale industry, product development, and business development. The book provides an introduction to Bio-mechatronics and provides the fundamentals, theory and wide-ranging applications of this methodology. Also included are case study like examples of the technology such as a Bioreactor for Microbial and Animal Cells, Artificial Liver Devices, and a Protein Purification System.